The Hepatic Sinusoid in Chronic Liver Disease: The Optimal Milieu for Cancer

The liver sinusoids are a unique type of microvascular beds. The specialized phenotype of sinusoidal cells is essential for their communication, and for the function of all hepatic cell types, including hepatocytes. Liver sinusoidal endothelial cells (LSECs) conform the inner layer of the sinusoids,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Albert Gibert-Ramos, David Sanfeliu-Redondo, Peio Aristu-Zabalza, Ana Martínez-Alcocer, Jordi Gracia-Sancho, Sergi Guixé-Muntet, Anabel Fernández-Iglesias
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hepatocellular carcinoma CLD cirrhosis LSEC HSC Kupffer cell Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/82e69200b4194c729f1fdff4d3c56886
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:82e69200b4194c729f1fdff4d3c56886
record_format	dspace
spelling	oai:doaj.org-article:82e69200b4194c729f1fdff4d3c568862021-11-25T17:03:13ZThe Hepatic Sinusoid in Chronic Liver Disease: The Optimal Milieu for Cancer10.3390/cancers132257192072-6694https://doaj.org/article/82e69200b4194c729f1fdff4d3c568862021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5719https://doaj.org/toc/2072-6694The liver sinusoids are a unique type of microvascular beds. The specialized phenotype of sinusoidal cells is essential for their communication, and for the function of all hepatic cell types, including hepatocytes. Liver sinusoidal endothelial cells (LSECs) conform the inner layer of the sinusoids, which is permeable due to the fenestrae across the cytoplasm; hepatic stellate cells (HSCs) surround LSECs, regulate the vascular tone, and synthetize the extracellular matrix, and Kupffer cells (KCs) are the liver-resident macrophages. Upon injury, the harmonic equilibrium in sinusoidal communication is disrupted, leading to phenotypic alterations that may affect the function of the whole liver if the damage persists. Understanding how the specialized sinusoidal cells work in coordination with each other in healthy livers and chronic liver disease is of the utmost importance for the discovery of new therapeutic targets and the design of novel pharmacological strategies. In this manuscript, we summarize the current knowledge on the role of sinusoidal cells and their communication both in health and chronic liver diseases, and their potential pharmacologic modulation. Finally, we discuss how alterations occurring during chronic injury may contribute to the development of hepatocellular carcinoma, which is usually developed in the background of chronic liver disease.Albert Gibert-RamosDavid Sanfeliu-RedondoPeio Aristu-ZabalzaAna Martínez-AlcocerJordi Gracia-SanchoSergi Guixé-MuntetAnabel Fernández-IglesiasMDPI AGarticlehepatocellular carcinomaCLDcirrhosisLSECHSCKupffer cellNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5719, p 5719 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocellular carcinoma CLD cirrhosis LSEC HSC Kupffer cell Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	hepatocellular carcinoma CLD cirrhosis LSEC HSC Kupffer cell Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Albert Gibert-Ramos David Sanfeliu-Redondo Peio Aristu-Zabalza Ana Martínez-Alcocer Jordi Gracia-Sancho Sergi Guixé-Muntet Anabel Fernández-Iglesias The Hepatic Sinusoid in Chronic Liver Disease: The Optimal Milieu for Cancer
description	The liver sinusoids are a unique type of microvascular beds. The specialized phenotype of sinusoidal cells is essential for their communication, and for the function of all hepatic cell types, including hepatocytes. Liver sinusoidal endothelial cells (LSECs) conform the inner layer of the sinusoids, which is permeable due to the fenestrae across the cytoplasm; hepatic stellate cells (HSCs) surround LSECs, regulate the vascular tone, and synthetize the extracellular matrix, and Kupffer cells (KCs) are the liver-resident macrophages. Upon injury, the harmonic equilibrium in sinusoidal communication is disrupted, leading to phenotypic alterations that may affect the function of the whole liver if the damage persists. Understanding how the specialized sinusoidal cells work in coordination with each other in healthy livers and chronic liver disease is of the utmost importance for the discovery of new therapeutic targets and the design of novel pharmacological strategies. In this manuscript, we summarize the current knowledge on the role of sinusoidal cells and their communication both in health and chronic liver diseases, and their potential pharmacologic modulation. Finally, we discuss how alterations occurring during chronic injury may contribute to the development of hepatocellular carcinoma, which is usually developed in the background of chronic liver disease.
format	article
author	Albert Gibert-Ramos David Sanfeliu-Redondo Peio Aristu-Zabalza Ana Martínez-Alcocer Jordi Gracia-Sancho Sergi Guixé-Muntet Anabel Fernández-Iglesias
author_facet	Albert Gibert-Ramos David Sanfeliu-Redondo Peio Aristu-Zabalza Ana Martínez-Alcocer Jordi Gracia-Sancho Sergi Guixé-Muntet Anabel Fernández-Iglesias
author_sort	Albert Gibert-Ramos
title	The Hepatic Sinusoid in Chronic Liver Disease: The Optimal Milieu for Cancer
title_short	The Hepatic Sinusoid in Chronic Liver Disease: The Optimal Milieu for Cancer
title_full	The Hepatic Sinusoid in Chronic Liver Disease: The Optimal Milieu for Cancer
title_fullStr	The Hepatic Sinusoid in Chronic Liver Disease: The Optimal Milieu for Cancer
title_full_unstemmed	The Hepatic Sinusoid in Chronic Liver Disease: The Optimal Milieu for Cancer
title_sort	hepatic sinusoid in chronic liver disease: the optimal milieu for cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/82e69200b4194c729f1fdff4d3c56886
work_keys_str_mv	AT albertgibertramos thehepaticsinusoidinchronicliverdiseasetheoptimalmilieuforcancer AT davidsanfeliuredondo thehepaticsinusoidinchronicliverdiseasetheoptimalmilieuforcancer AT peioaristuzabalza thehepaticsinusoidinchronicliverdiseasetheoptimalmilieuforcancer AT anamartinezalcocer thehepaticsinusoidinchronicliverdiseasetheoptimalmilieuforcancer AT jordigraciasancho thehepaticsinusoidinchronicliverdiseasetheoptimalmilieuforcancer AT sergiguixemuntet thehepaticsinusoidinchronicliverdiseasetheoptimalmilieuforcancer AT anabelfernandeziglesias thehepaticsinusoidinchronicliverdiseasetheoptimalmilieuforcancer AT albertgibertramos hepaticsinusoidinchronicliverdiseasetheoptimalmilieuforcancer AT davidsanfeliuredondo hepaticsinusoidinchronicliverdiseasetheoptimalmilieuforcancer AT peioaristuzabalza hepaticsinusoidinchronicliverdiseasetheoptimalmilieuforcancer AT anamartinezalcocer hepaticsinusoidinchronicliverdiseasetheoptimalmilieuforcancer AT jordigraciasancho hepaticsinusoidinchronicliverdiseasetheoptimalmilieuforcancer AT sergiguixemuntet hepaticsinusoidinchronicliverdiseasetheoptimalmilieuforcancer AT anabelfernandeziglesias hepaticsinusoidinchronicliverdiseasetheoptimalmilieuforcancer
_version_	1718412786992676864

The Hepatic Sinusoid in Chronic Liver Disease: The Optimal Milieu for Cancer

Ejemplares similares