mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis

The authors previously showed that mTOR controls the function of regulatory T cells. Here they show how this mTOR signaling orchestrates homeostasis of Treg-cell subsets and prevents fatal autoimmunity.

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Autores principales:	Nicole M. Chapman, Hu Zeng, Thanh-Long M. Nguyen, Yanyan Wang, Peter Vogel, Yogesh Dhungana, Xiaojing Liu, Geoffrey Neale, Jason W. Locasale, Hongbo Chi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/82e6c310fa634555988c8e483a046fc2
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spelling	oai:doaj.org-article:82e6c310fa634555988c8e483a046fc22021-12-02T14:39:06ZmTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis10.1038/s41467-018-04392-52041-1723https://doaj.org/article/82e6c310fa634555988c8e483a046fc22018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04392-5https://doaj.org/toc/2041-1723The authors previously showed that mTOR controls the function of regulatory T cells. Here they show how this mTOR signaling orchestrates homeostasis of Treg-cell subsets and prevents fatal autoimmunity.Nicole M. ChapmanHu ZengThanh-Long M. NguyenYanyan WangPeter VogelYogesh DhunganaXiaojing LiuGeoffrey NealeJason W. LocasaleHongbo ChiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicole M. Chapman Hu Zeng Thanh-Long M. Nguyen Yanyan Wang Peter Vogel Yogesh Dhungana Xiaojing Liu Geoffrey Neale Jason W. Locasale Hongbo Chi mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis
description	The authors previously showed that mTOR controls the function of regulatory T cells. Here they show how this mTOR signaling orchestrates homeostasis of Treg-cell subsets and prevents fatal autoimmunity.
format	article
author	Nicole M. Chapman Hu Zeng Thanh-Long M. Nguyen Yanyan Wang Peter Vogel Yogesh Dhungana Xiaojing Liu Geoffrey Neale Jason W. Locasale Hongbo Chi
author_facet	Nicole M. Chapman Hu Zeng Thanh-Long M. Nguyen Yanyan Wang Peter Vogel Yogesh Dhungana Xiaojing Liu Geoffrey Neale Jason W. Locasale Hongbo Chi
author_sort	Nicole M. Chapman
title	mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis
title_short	mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis
title_full	mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis
title_fullStr	mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis
title_full_unstemmed	mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis
title_sort	mtor coordinates transcriptional programs and mitochondrial metabolism of activated treg subsets to protect tissue homeostasis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/82e6c310fa634555988c8e483a046fc2
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mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis

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