Structural basis for Ccd1 auto-inhibition in the Wnt pathway through homomerization of the DIX domain

Structural basis for Ccd1 auto-inhibition in the Wnt pathway through homomerization of the DIX domain

Abstract Wnt signaling plays an important role in governing cell fate decisions. Coiled-coil-DIX1 (Ccd1), Dishevelled (Dvl), and Axin are signaling proteins that regulate the canonical pathway by controlling the stability of a key signal transducer β-catenin. These proteins contain the DIX domain wi...

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Autores principales: Shin-ichi Terawaki, Shohei Fujita, Takuya Katsutani, Kensuke Shiomi, Kazuko Keino-Masu, Masayuki Masu, Kaori Wakamatsu, Naoki Shibata, Yoshiki Higuchi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/82ea2c14f6a04fdfac2aa1e522bd3b63
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