Treatment of systemic sclerosis: potential role for stem cell transplantation

Treatment of systemic sclerosis: potential role for stem cell transplantation

Wen Xiong, Chris T DerkDivision of Rheumatology, Thomas Jefferson University, Philadelphia, PA, 19107, USAAbstract: Hematopoietic stem cell transplantation may “reset” the immune reconstitution and induce self tolerance of autoreactive lymphocytes, and has been explored i...

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Autores principales: Wen Xiong, Chris T Derk
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2009
Materias:
Cytology
QH573-671
Acceso en línea:https://doaj.org/article/82ea434065de4190b61d8b28a94fb9f6
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spelling oai:doaj.org-article:82ea434065de4190b61d8b28a94fb9f62021-12-02T02:59:33ZTreatment of systemic sclerosis: potential role for stem cell transplantation1178-6957https://doaj.org/article/82ea434065de4190b61d8b28a94fb9f62009-11-01T00:00:00Zhttp://www.dovepress.com/treatment-of-systemic-sclerosis-potential-role-for-stem-cell-transplan-a3748https://doaj.org/toc/1178-6957Wen Xiong, Chris T DerkDivision of Rheumatology, Thomas Jefferson University, Philadelphia, PA, 19107, USAAbstract: Hematopoietic stem cell transplantation may “reset” the immune reconstitution and induce self tolerance of autoreactive lymphocytes, and has been explored in the treatments for systemic sclerosis. Phase I/II trials have shown a satisfactory risk benefit ratio. The true benefit will be identified by two ongoing prospective, randomized phase III trials. Multipotent mesenchymal stromal cells (MSCs) possess antiproliferative, anti-inflammatory, and immunosuppressive properties. The use of MSCs has showed successful responses in patients with severe steroid-resistant acute graft versus host disease in phase II trials, and may be a potentially promising option for patients with systemic sclerosis.Keywords: scleroderma, systemic sclerosis, treatment, stem cells, transplant Wen XiongChris T DerkDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2009, Iss default, Pp 1-9 (2009)
institution DOAJ
collection DOAJ
language EN
topic Cytology
QH573-671
spellingShingle Cytology
QH573-671
Wen Xiong
Chris T Derk
Treatment of systemic sclerosis: potential role for stem cell transplantation
description Wen Xiong, Chris T DerkDivision of Rheumatology, Thomas Jefferson University, Philadelphia, PA, 19107, USAAbstract: Hematopoietic stem cell transplantation may “reset” the immune reconstitution and induce self tolerance of autoreactive lymphocytes, and has been explored in the treatments for systemic sclerosis. Phase I/II trials have shown a satisfactory risk benefit ratio. The true benefit will be identified by two ongoing prospective, randomized phase III trials. Multipotent mesenchymal stromal cells (MSCs) possess antiproliferative, anti-inflammatory, and immunosuppressive properties. The use of MSCs has showed successful responses in patients with severe steroid-resistant acute graft versus host disease in phase II trials, and may be a potentially promising option for patients with systemic sclerosis.Keywords: scleroderma, systemic sclerosis, treatment, stem cells, transplant
format article
author Wen Xiong
Chris T Derk
author_facet Wen Xiong
Chris T Derk
author_sort Wen Xiong
title Treatment of systemic sclerosis: potential role for stem cell transplantation
title_short Treatment of systemic sclerosis: potential role for stem cell transplantation
title_full Treatment of systemic sclerosis: potential role for stem cell transplantation
title_fullStr Treatment of systemic sclerosis: potential role for stem cell transplantation
title_full_unstemmed Treatment of systemic sclerosis: potential role for stem cell transplantation
title_sort treatment of systemic sclerosis: potential role for stem cell transplantation
publisher Dove Medical Press
publishDate 2009
url https://doaj.org/article/82ea434065de4190b61d8b28a94fb9f6
work_keys_str_mv AT wenxiong treatmentofsystemicsclerosispotentialroleforstemcelltransplantation
AT christderk treatmentofsystemicsclerosispotentialroleforstemcelltransplantation
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