Diuretics prime plant immunity in Arabidopsis thaliana.

Plant activators are agrochemicals that activate the plant immune system, thereby enhancing disease resistance. Due to their prophylactic and durable effects on a wide spectrum of diseases, plant activators can provide synergistic crop protection when used in combination with traditional pest contro...

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Autores principales:	Yoshiteru Noutoshi, Mika Ikeda, Ken Shirasu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/82eb141abd1547d1957022bcb947b3b5
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spelling	oai:doaj.org-article:82eb141abd1547d1957022bcb947b3b52021-11-18T08:10:42ZDiuretics prime plant immunity in Arabidopsis thaliana.1932-620310.1371/journal.pone.0048443https://doaj.org/article/82eb141abd1547d1957022bcb947b3b52012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23144763/?tool=EBIhttps://doaj.org/toc/1932-6203Plant activators are agrochemicals that activate the plant immune system, thereby enhancing disease resistance. Due to their prophylactic and durable effects on a wide spectrum of diseases, plant activators can provide synergistic crop protection when used in combination with traditional pest controls. Although plant activators have achieved great success in wet-rice farming practices in Asia, their use is still limited. To isolate novel plant activators applicable to other crops, we screened a chemical library using a method that can selectively identify immune-priming compounds. Here, we report the isolation and characterization of three diuretics, bumetanide, bendroflumethiazide and clopamide, as immune-priming compounds. These drugs upregulate the immunity-related cell death of Arabidopsis suspension-cultured cells induced with an avirulent strain of Pseudomonas syringae pv. tomato in a concentration-dependent manner. The application of these compounds to Arabidopsis plants confers disease resistance to not only the avirulent but also a virulent strain of the pathogen. Unlike salicylic acid, an endogenous phytohormone that governs disease resistance in response to biotrophic pathogens, the three diuretic compounds analyzed here do not induce PR1 or inhibit plant growth, showing potential as lead compounds in a practical application.Yoshiteru NoutoshiMika IkedaKen ShirasuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e48443 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoshiteru Noutoshi Mika Ikeda Ken Shirasu Diuretics prime plant immunity in Arabidopsis thaliana.
description	Plant activators are agrochemicals that activate the plant immune system, thereby enhancing disease resistance. Due to their prophylactic and durable effects on a wide spectrum of diseases, plant activators can provide synergistic crop protection when used in combination with traditional pest controls. Although plant activators have achieved great success in wet-rice farming practices in Asia, their use is still limited. To isolate novel plant activators applicable to other crops, we screened a chemical library using a method that can selectively identify immune-priming compounds. Here, we report the isolation and characterization of three diuretics, bumetanide, bendroflumethiazide and clopamide, as immune-priming compounds. These drugs upregulate the immunity-related cell death of Arabidopsis suspension-cultured cells induced with an avirulent strain of Pseudomonas syringae pv. tomato in a concentration-dependent manner. The application of these compounds to Arabidopsis plants confers disease resistance to not only the avirulent but also a virulent strain of the pathogen. Unlike salicylic acid, an endogenous phytohormone that governs disease resistance in response to biotrophic pathogens, the three diuretic compounds analyzed here do not induce PR1 or inhibit plant growth, showing potential as lead compounds in a practical application.
format	article
author	Yoshiteru Noutoshi Mika Ikeda Ken Shirasu
author_facet	Yoshiteru Noutoshi Mika Ikeda Ken Shirasu
author_sort	Yoshiteru Noutoshi
title	Diuretics prime plant immunity in Arabidopsis thaliana.
title_short	Diuretics prime plant immunity in Arabidopsis thaliana.
title_full	Diuretics prime plant immunity in Arabidopsis thaliana.
title_fullStr	Diuretics prime plant immunity in Arabidopsis thaliana.
title_full_unstemmed	Diuretics prime plant immunity in Arabidopsis thaliana.
title_sort	diuretics prime plant immunity in arabidopsis thaliana.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/82eb141abd1547d1957022bcb947b3b5
work_keys_str_mv	AT yoshiterunoutoshi diureticsprimeplantimmunityinarabidopsisthaliana AT mikaikeda diureticsprimeplantimmunityinarabidopsisthaliana AT kenshirasu diureticsprimeplantimmunityinarabidopsisthaliana
_version_	1718422118904889344

Diuretics prime plant immunity in Arabidopsis thaliana.

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