In Vitro Hair Growth Promoting Effect of a Noncrosslinked Hyaluronic Acid in Human Dermal Papilla Cells

Dermal papilla cells (DPCs) are a source of nutrients and growth factors, which support the proliferation and growth of keratinocytes as well as promoting the induction of new hair follicles and maintenance of hair growth. The protection from reactive oxygen species (ROS) and the promotion of angiog...

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Autores principales:	Nicola Zerbinati, Sabrina Sommatis, Cristina Maccario, Maria C. Capillo, Serena Di Francesco, Raffaele Rauso, Marina Protasoni, Edoardo D’Este, Daniela Dalla Gasperina, Roberto Mocchi
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/82eb353c3a8d45d3baa66b6385bd6977
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spelling	oai:doaj.org-article:82eb353c3a8d45d3baa66b6385bd69772021-11-08T02:37:17ZIn Vitro Hair Growth Promoting Effect of a Noncrosslinked Hyaluronic Acid in Human Dermal Papilla Cells2314-614110.1155/2021/5598110https://doaj.org/article/82eb353c3a8d45d3baa66b6385bd69772021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5598110https://doaj.org/toc/2314-6141Dermal papilla cells (DPCs) are a source of nutrients and growth factors, which support the proliferation and growth of keratinocytes as well as promoting the induction of new hair follicles and maintenance of hair growth. The protection from reactive oxygen species (ROS) and the promotion of angiogenesis are considered two of the basal mechanisms to preserve the growth of the hair follicle. In this study, a noncrosslinked hyaluronic acid (HA) filler (HYDRO DELUXE BIO, Matex Lab S.p.A.) containing several amino acids was tested with in vitro assays on human follicle dermal papilla cells (HFDPCs). The experiments were carried out to investigate the possible protection against oxidative stress and the ability to increase the vascular endothelial growth factor (VEGF) release. The results demonstrated the restoration of cell viability against UVB-induced cytotoxicity and an increase in the VEGF secretion. These data demonstrate the capability of the product to modulate human dermal papilla cells, suggesting a future use in mesotherapy, a minimally invasive local intradermal therapy (LIT), after further clinical investigations.Nicola ZerbinatiSabrina SommatisCristina MaccarioMaria C. CapilloSerena Di FrancescoRaffaele RausoMarina ProtasoniEdoardo D’EsteDaniela Dalla GasperinaRoberto MocchiHindawi LimitedarticleMedicineRENBioMed Research International, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Nicola Zerbinati Sabrina Sommatis Cristina Maccario Maria C. Capillo Serena Di Francesco Raffaele Rauso Marina Protasoni Edoardo D’Este Daniela Dalla Gasperina Roberto Mocchi In Vitro Hair Growth Promoting Effect of a Noncrosslinked Hyaluronic Acid in Human Dermal Papilla Cells
description	Dermal papilla cells (DPCs) are a source of nutrients and growth factors, which support the proliferation and growth of keratinocytes as well as promoting the induction of new hair follicles and maintenance of hair growth. The protection from reactive oxygen species (ROS) and the promotion of angiogenesis are considered two of the basal mechanisms to preserve the growth of the hair follicle. In this study, a noncrosslinked hyaluronic acid (HA) filler (HYDRO DELUXE BIO, Matex Lab S.p.A.) containing several amino acids was tested with in vitro assays on human follicle dermal papilla cells (HFDPCs). The experiments were carried out to investigate the possible protection against oxidative stress and the ability to increase the vascular endothelial growth factor (VEGF) release. The results demonstrated the restoration of cell viability against UVB-induced cytotoxicity and an increase in the VEGF secretion. These data demonstrate the capability of the product to modulate human dermal papilla cells, suggesting a future use in mesotherapy, a minimally invasive local intradermal therapy (LIT), after further clinical investigations.
format	article
author	Nicola Zerbinati Sabrina Sommatis Cristina Maccario Maria C. Capillo Serena Di Francesco Raffaele Rauso Marina Protasoni Edoardo D’Este Daniela Dalla Gasperina Roberto Mocchi
author_facet	Nicola Zerbinati Sabrina Sommatis Cristina Maccario Maria C. Capillo Serena Di Francesco Raffaele Rauso Marina Protasoni Edoardo D’Este Daniela Dalla Gasperina Roberto Mocchi
author_sort	Nicola Zerbinati
title	In Vitro Hair Growth Promoting Effect of a Noncrosslinked Hyaluronic Acid in Human Dermal Papilla Cells
title_short	In Vitro Hair Growth Promoting Effect of a Noncrosslinked Hyaluronic Acid in Human Dermal Papilla Cells
title_full	In Vitro Hair Growth Promoting Effect of a Noncrosslinked Hyaluronic Acid in Human Dermal Papilla Cells
title_fullStr	In Vitro Hair Growth Promoting Effect of a Noncrosslinked Hyaluronic Acid in Human Dermal Papilla Cells
title_full_unstemmed	In Vitro Hair Growth Promoting Effect of a Noncrosslinked Hyaluronic Acid in Human Dermal Papilla Cells
title_sort	in vitro hair growth promoting effect of a noncrosslinked hyaluronic acid in human dermal papilla cells
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/82eb353c3a8d45d3baa66b6385bd6977
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In Vitro Hair Growth Promoting Effect of a Noncrosslinked Hyaluronic Acid in Human Dermal Papilla Cells

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