A binding protein regulates myosin-7a dimerization and actin bundle assembly

Myosin-7a is found in actin bundles, microvilli and stereocilia, and plays conserved roles in hearing and vision. Here the authors identify M7BP, a myosin-7a binding protein that activates and dimerizes myosin-7a, enabling cargo transport and assembly of actin bundles and filopodia-like protrusions

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Autores principales:	Rong Liu, Neil Billington, Yi Yang, Charles Bond, Amy Hong, Verl Siththanandan, Yasuharu Takagi, James R. Sellers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/82ee430ef28b4669aae273c5e81f0e66
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spelling	oai:doaj.org-article:82ee430ef28b4669aae273c5e81f0e662021-12-02T14:16:14ZA binding protein regulates myosin-7a dimerization and actin bundle assembly10.1038/s41467-020-20864-z2041-1723https://doaj.org/article/82ee430ef28b4669aae273c5e81f0e662021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20864-zhttps://doaj.org/toc/2041-1723Myosin-7a is found in actin bundles, microvilli and stereocilia, and plays conserved roles in hearing and vision. Here the authors identify M7BP, a myosin-7a binding protein that activates and dimerizes myosin-7a, enabling cargo transport and assembly of actin bundles and filopodia-like protrusionsRong LiuNeil BillingtonYi YangCharles BondAmy HongVerl SiththanandanYasuharu TakagiJames R. SellersNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rong Liu Neil Billington Yi Yang Charles Bond Amy Hong Verl Siththanandan Yasuharu Takagi James R. Sellers A binding protein regulates myosin-7a dimerization and actin bundle assembly
description	Myosin-7a is found in actin bundles, microvilli and stereocilia, and plays conserved roles in hearing and vision. Here the authors identify M7BP, a myosin-7a binding protein that activates and dimerizes myosin-7a, enabling cargo transport and assembly of actin bundles and filopodia-like protrusions
format	article
author	Rong Liu Neil Billington Yi Yang Charles Bond Amy Hong Verl Siththanandan Yasuharu Takagi James R. Sellers
author_facet	Rong Liu Neil Billington Yi Yang Charles Bond Amy Hong Verl Siththanandan Yasuharu Takagi James R. Sellers
author_sort	Rong Liu
title	A binding protein regulates myosin-7a dimerization and actin bundle assembly
title_short	A binding protein regulates myosin-7a dimerization and actin bundle assembly
title_full	A binding protein regulates myosin-7a dimerization and actin bundle assembly
title_fullStr	A binding protein regulates myosin-7a dimerization and actin bundle assembly
title_full_unstemmed	A binding protein regulates myosin-7a dimerization and actin bundle assembly
title_sort	binding protein regulates myosin-7a dimerization and actin bundle assembly
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/82ee430ef28b4669aae273c5e81f0e66
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A binding protein regulates myosin-7a dimerization and actin bundle assembly

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