Update and optimal use of a brinzolamide-timolol fixed combination in open-angle glaucoma and ocular hypertension

Misha F Syed, Emma KR LoucksDepartment of Ophthalmology and Visual Sciences, The University of Texas Medical Branch, Galveston, TX, USAAbstract: Glaucoma encompasses a wide clinical spectrum of disease, with the common pathophysiology of progressive optic neuropathy leading to visual field loss. Ele...

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Autores principales:	Syed MF, Loucks EKR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/82efcbb2d50d4fdc9496735fe2cdb8d4
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spelling	oai:doaj.org-article:82efcbb2d50d4fdc9496735fe2cdb8d42021-12-02T02:49:32ZUpdate and optimal use of a brinzolamide-timolol fixed combination in open-angle glaucoma and ocular hypertension1177-54671177-5483https://doaj.org/article/82efcbb2d50d4fdc9496735fe2cdb8d42011-09-01T00:00:00Zhttp://www.dovepress.com/update-and-optimal-use-of-a-brinzolamide-timolol-fixed-combination-in--a8237https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Misha F Syed, Emma KR LoucksDepartment of Ophthalmology and Visual Sciences, The University of Texas Medical Branch, Galveston, TX, USAAbstract: Glaucoma encompasses a wide clinical spectrum of disease, with the common pathophysiology of progressive optic neuropathy leading to visual field loss. Elevated intraocular pressure (IOP) is a key risk factor in disease progression. Treatment is aimed at reduction of IOP to minimize continued optic nerve head damage. Pharmacologic treatment with various classes of IOP-lowering medications is generally employed before more aggressive surgical interventions. Monotherapy is generally accepted as initial therapy for glaucoma, but at least half of patients may require more than one IOP-lowering medication. One option is the fixed combination of brinzolamide 1% and timolol maleate 0.5%, which is commercially available in some countries as Azarga&reg; for treatment of glaucoma not adequately responsive to monotherapy. These agents may also be used in an unfixed fashion, but fixed combination therapy is generally more convenient for patients, which may result in improved compliance, a reduction of the &quot;washout effect&quot; from instilling multiple drops, and a potential reduction in the side effects related to multiple doses of preservatives.Keywords: brinzolamide, timolol, glaucoma, fixed combination therapy, ocular hypertensionSyed MFLoucks EKRDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 1291-1296 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Syed MF Loucks EKR Update and optimal use of a brinzolamide-timolol fixed combination in open-angle glaucoma and ocular hypertension
description	Misha F Syed, Emma KR LoucksDepartment of Ophthalmology and Visual Sciences, The University of Texas Medical Branch, Galveston, TX, USAAbstract: Glaucoma encompasses a wide clinical spectrum of disease, with the common pathophysiology of progressive optic neuropathy leading to visual field loss. Elevated intraocular pressure (IOP) is a key risk factor in disease progression. Treatment is aimed at reduction of IOP to minimize continued optic nerve head damage. Pharmacologic treatment with various classes of IOP-lowering medications is generally employed before more aggressive surgical interventions. Monotherapy is generally accepted as initial therapy for glaucoma, but at least half of patients may require more than one IOP-lowering medication. One option is the fixed combination of brinzolamide 1% and timolol maleate 0.5%, which is commercially available in some countries as Azarga&reg; for treatment of glaucoma not adequately responsive to monotherapy. These agents may also be used in an unfixed fashion, but fixed combination therapy is generally more convenient for patients, which may result in improved compliance, a reduction of the &quot;washout effect&quot; from instilling multiple drops, and a potential reduction in the side effects related to multiple doses of preservatives.Keywords: brinzolamide, timolol, glaucoma, fixed combination therapy, ocular hypertension
format	article
author	Syed MF Loucks EKR
author_facet	Syed MF Loucks EKR
author_sort	Syed MF
title	Update and optimal use of a brinzolamide-timolol fixed combination in open-angle glaucoma and ocular hypertension
title_short	Update and optimal use of a brinzolamide-timolol fixed combination in open-angle glaucoma and ocular hypertension
title_full	Update and optimal use of a brinzolamide-timolol fixed combination in open-angle glaucoma and ocular hypertension
title_fullStr	Update and optimal use of a brinzolamide-timolol fixed combination in open-angle glaucoma and ocular hypertension
title_full_unstemmed	Update and optimal use of a brinzolamide-timolol fixed combination in open-angle glaucoma and ocular hypertension
title_sort	update and optimal use of a brinzolamide-timolol fixed combination in open-angle glaucoma and ocular hypertension
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/82efcbb2d50d4fdc9496735fe2cdb8d4
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Update and optimal use of a brinzolamide-timolol fixed combination in open-angle glaucoma and ocular hypertension

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