Characteristics and Long-Term Ablation Outcomes of Supraventricular Arrhythmias in Hypertrophic Cardiomyopathy: A 10-Year, Single-Center Experience

Background: A variety of supraventricular arrhythmias (SVAs) may occur in patients with hypertrophic cardiomyopathy (HCM). The characteristics and long-term ablation outcomes of different types of SVAs in HCM have not been comprehensively investigated.Methods: We retrospectively enrolled 101 consecu...

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Autores principales:	Hong-Da Zhang, Lei Ding, Si-Xian Weng, Bin Zhou, Xiao-Tong Ding, Li-Xing Hu, Ying-Jie Qi, Feng-Yuan Yu, Tian-Jie Feng, Jing-Tao Zhang, Pi-Hua Fang, Wei Hua, Shu Zhang, Min Tang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	hypertrophic cardiomyopathy supraventricular arrhythmia atrial fibrillation catheter ablation outcomes Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/82f3818fc8874738bea5aa664a3fc0f0
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spelling	oai:doaj.org-article:82f3818fc8874738bea5aa664a3fc0f02021-11-12T05:12:57ZCharacteristics and Long-Term Ablation Outcomes of Supraventricular Arrhythmias in Hypertrophic Cardiomyopathy: A 10-Year, Single-Center Experience2297-055X10.3389/fcvm.2021.766571https://doaj.org/article/82f3818fc8874738bea5aa664a3fc0f02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.766571/fullhttps://doaj.org/toc/2297-055XBackground: A variety of supraventricular arrhythmias (SVAs) may occur in patients with hypertrophic cardiomyopathy (HCM). The characteristics and long-term ablation outcomes of different types of SVAs in HCM have not been comprehensively investigated.Methods: We retrospectively enrolled 101 consecutive patients with HCM who were referred to the electrophysiology and arrhythmia service from May 2010 to October 2020. The clinical features and ablation outcomes were analyzed.Results: Seventy-eight patients had SVAs, which comprised 50 (64.1%) cases of atrial fibrillation (AF), 16 (20.5%) of atrial flutter (AFL), 15 (19.2%) of atrioventricular reentrant tachycardia (AVRT), 11 (14.1%) of atrial arrhythmia (AT), and 3 (3.8%) of atrioventricular nodal reentrant tachycardia (AVNRT). Thirty-four patients underwent catheter ablation and were followed up for a median (interquartile range) of 58.5 (82.9) months. There was no recurrence in patients with non-AF SVAs. In patients with AF, the 1- and 7-year AF-free survival rates were 87.5 and 49.5%, respectively. A receiver operator characteristic analysis showed that a greater left ventricular end-diastolic dimension (LVEDD) was associated with a higher recurrence of AF, with an optimum cutoff value of 47 mm (c-statistic = 0.91, p = 0.011, sensitivity = 1.00, specificity = 0.82). In Kaplan–Meier analysis, patients with a LVEDD ≥ 47 mm had worse AF-free survival than those with a LVEDD <47 mm (log-rank p = 0.014).Conclusions: In this unique population of HCM, AF was the most common SVA, followed in order by AFL, AVRT, AT, and AVNRT. The long-term catheter ablation outcome for non-AF SVAs in HCM is satisfactory. A greater LVEDD predicts AF recurrence after catheter ablation in patients with HCM.Hong-Da ZhangLei DingSi-Xian WengBin ZhouXiao-Tong DingLi-Xing HuYing-Jie QiFeng-Yuan YuTian-Jie FengJing-Tao ZhangPi-Hua FangWei HuaShu ZhangMin TangFrontiers Media S.A.articlehypertrophic cardiomyopathysupraventricular arrhythmiaatrial fibrillationcatheter ablationoutcomesDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypertrophic cardiomyopathy supraventricular arrhythmia atrial fibrillation catheter ablation outcomes Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	hypertrophic cardiomyopathy supraventricular arrhythmia atrial fibrillation catheter ablation outcomes Diseases of the circulatory (Cardiovascular) system RC666-701 Hong-Da Zhang Lei Ding Si-Xian Weng Bin Zhou Xiao-Tong Ding Li-Xing Hu Ying-Jie Qi Feng-Yuan Yu Tian-Jie Feng Jing-Tao Zhang Pi-Hua Fang Wei Hua Shu Zhang Min Tang Characteristics and Long-Term Ablation Outcomes of Supraventricular Arrhythmias in Hypertrophic Cardiomyopathy: A 10-Year, Single-Center Experience
description	Background: A variety of supraventricular arrhythmias (SVAs) may occur in patients with hypertrophic cardiomyopathy (HCM). The characteristics and long-term ablation outcomes of different types of SVAs in HCM have not been comprehensively investigated.Methods: We retrospectively enrolled 101 consecutive patients with HCM who were referred to the electrophysiology and arrhythmia service from May 2010 to October 2020. The clinical features and ablation outcomes were analyzed.Results: Seventy-eight patients had SVAs, which comprised 50 (64.1%) cases of atrial fibrillation (AF), 16 (20.5%) of atrial flutter (AFL), 15 (19.2%) of atrioventricular reentrant tachycardia (AVRT), 11 (14.1%) of atrial arrhythmia (AT), and 3 (3.8%) of atrioventricular nodal reentrant tachycardia (AVNRT). Thirty-four patients underwent catheter ablation and were followed up for a median (interquartile range) of 58.5 (82.9) months. There was no recurrence in patients with non-AF SVAs. In patients with AF, the 1- and 7-year AF-free survival rates were 87.5 and 49.5%, respectively. A receiver operator characteristic analysis showed that a greater left ventricular end-diastolic dimension (LVEDD) was associated with a higher recurrence of AF, with an optimum cutoff value of 47 mm (c-statistic = 0.91, p = 0.011, sensitivity = 1.00, specificity = 0.82). In Kaplan–Meier analysis, patients with a LVEDD ≥ 47 mm had worse AF-free survival than those with a LVEDD <47 mm (log-rank p = 0.014).Conclusions: In this unique population of HCM, AF was the most common SVA, followed in order by AFL, AVRT, AT, and AVNRT. The long-term catheter ablation outcome for non-AF SVAs in HCM is satisfactory. A greater LVEDD predicts AF recurrence after catheter ablation in patients with HCM.
format	article
author	Hong-Da Zhang Lei Ding Si-Xian Weng Bin Zhou Xiao-Tong Ding Li-Xing Hu Ying-Jie Qi Feng-Yuan Yu Tian-Jie Feng Jing-Tao Zhang Pi-Hua Fang Wei Hua Shu Zhang Min Tang
author_facet	Hong-Da Zhang Lei Ding Si-Xian Weng Bin Zhou Xiao-Tong Ding Li-Xing Hu Ying-Jie Qi Feng-Yuan Yu Tian-Jie Feng Jing-Tao Zhang Pi-Hua Fang Wei Hua Shu Zhang Min Tang
author_sort	Hong-Da Zhang
title	Characteristics and Long-Term Ablation Outcomes of Supraventricular Arrhythmias in Hypertrophic Cardiomyopathy: A 10-Year, Single-Center Experience
title_short	Characteristics and Long-Term Ablation Outcomes of Supraventricular Arrhythmias in Hypertrophic Cardiomyopathy: A 10-Year, Single-Center Experience
title_full	Characteristics and Long-Term Ablation Outcomes of Supraventricular Arrhythmias in Hypertrophic Cardiomyopathy: A 10-Year, Single-Center Experience
title_fullStr	Characteristics and Long-Term Ablation Outcomes of Supraventricular Arrhythmias in Hypertrophic Cardiomyopathy: A 10-Year, Single-Center Experience
title_full_unstemmed	Characteristics and Long-Term Ablation Outcomes of Supraventricular Arrhythmias in Hypertrophic Cardiomyopathy: A 10-Year, Single-Center Experience
title_sort	characteristics and long-term ablation outcomes of supraventricular arrhythmias in hypertrophic cardiomyopathy: a 10-year, single-center experience
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/82f3818fc8874738bea5aa664a3fc0f0
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Characteristics and Long-Term Ablation Outcomes of Supraventricular Arrhythmias in Hypertrophic Cardiomyopathy: A 10-Year, Single-Center Experience

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