Genotoxic and oxidative effect of duloxetine on mouse brain and liver tissues

Abstract We evaluated the duloxetine DNA damaging capacity utilizing the comet assay applied to mouse brain and liver cells, as well as its DNA, lipid, protein, and nitric oxide oxidative potential in the same cells. A kinetic time/dose strategy showed the effect of 2, 20, and 200 mg/kg of the drug...

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Autores principales: Isela Álvarez-González, Scarlett Camacho-Cantera, Patricia Gómez-González, Michael J. Rendón Barrón, José A. Morales-González, Eduardo O. Madrigal-Santillán, Rogelio Paniagua-Pérez, Eduardo Madrigal-Bujaidar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/82f7095f37b346aea7251153626e1055
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