Evaluation of GeneXpert vanA/vanB in the early diagnosis of vancomycin-resistant enterococci infection.

<h4>Purpose</h4>Vancomycin-resistant enterococci infection is a worrying worldwide clinical problem. To evaluate the accuracy of GeneXpert vanA/vanB in the diagnosis of VRE, we conducted a systematic review in the study.<h4>Methods</h4>Experimental data were extracted from pu...

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Autores principales:	Zhuo-Lei Li, Qi-Bing Luo, Shan-Shan Xiao, Ze-Hong Lin, Ye-Ling Liu, Meng-Yi Han, Jing-Hua Zhong, Tian-Xing Ji, Xu-Guang Guo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/82f7eea1c9cc41118b74a68ba35a065e
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spelling	oai:doaj.org-article:82f7eea1c9cc41118b74a68ba35a065e2021-12-02T20:23:26ZEvaluation of GeneXpert vanA/vanB in the early diagnosis of vancomycin-resistant enterococci infection.1935-27271935-273510.1371/journal.pntd.0009869https://doaj.org/article/82f7eea1c9cc41118b74a68ba35a065e2021-11-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009869https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Purpose</h4>Vancomycin-resistant enterococci infection is a worrying worldwide clinical problem. To evaluate the accuracy of GeneXpert vanA/vanB in the diagnosis of VRE, we conducted a systematic review in the study.<h4>Methods</h4>Experimental data were extracted from publications until May 03 2021 related to the diagnostic accuracy of GeneXpert vanA/vanB for VRE in PubMed, Embase, Web of Science and the Cochrane Library. The accuracy of GeneXpert vanA/vanB for VRE was evaluated using summary receiver to operate characteristic curve, pooled sensitivity, pooled specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio.<h4>Results</h4>8 publications were divided into 3 groups according to two golden standard references, vanA and vanB group, vanA group, vanB group, including 6 researches, 5 researches and 5 researches, respectively. The pooled sensitivity and specificity of group vanA and vanB were 0.96 (95% CI, 0.93-0.98) and 0.90 (95% CI, 0.88-0.91) respectively. The DOR was 440.77 (95% CI, 37.92-5123.55). The pooled sensitivity and specificity of group vanA were 0.86 (95% CI, 0.81-0.90) and 0.99 (95% CI, 0.99-0.99) respectively, and those of group vanB were 0.85 (95% CI, 0.63-0.97) and 0.82 (95% CI, 0.80-0.83) respectively.<h4>Conclusion</h4>GeneXpert vanA/vanB can diagnose VRE with high-accuracy and shows greater accuracy in diagnosing vanA.Zhuo-Lei LiQi-Bing LuoShan-Shan XiaoZe-Hong LinYe-Ling LiuMeng-Yi HanJing-Hua ZhongTian-Xing JiXu-Guang GuoPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009869 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Zhuo-Lei Li Qi-Bing Luo Shan-Shan Xiao Ze-Hong Lin Ye-Ling Liu Meng-Yi Han Jing-Hua Zhong Tian-Xing Ji Xu-Guang Guo Evaluation of GeneXpert vanA/vanB in the early diagnosis of vancomycin-resistant enterococci infection.
description	<h4>Purpose</h4>Vancomycin-resistant enterococci infection is a worrying worldwide clinical problem. To evaluate the accuracy of GeneXpert vanA/vanB in the diagnosis of VRE, we conducted a systematic review in the study.<h4>Methods</h4>Experimental data were extracted from publications until May 03 2021 related to the diagnostic accuracy of GeneXpert vanA/vanB for VRE in PubMed, Embase, Web of Science and the Cochrane Library. The accuracy of GeneXpert vanA/vanB for VRE was evaluated using summary receiver to operate characteristic curve, pooled sensitivity, pooled specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio.<h4>Results</h4>8 publications were divided into 3 groups according to two golden standard references, vanA and vanB group, vanA group, vanB group, including 6 researches, 5 researches and 5 researches, respectively. The pooled sensitivity and specificity of group vanA and vanB were 0.96 (95% CI, 0.93-0.98) and 0.90 (95% CI, 0.88-0.91) respectively. The DOR was 440.77 (95% CI, 37.92-5123.55). The pooled sensitivity and specificity of group vanA were 0.86 (95% CI, 0.81-0.90) and 0.99 (95% CI, 0.99-0.99) respectively, and those of group vanB were 0.85 (95% CI, 0.63-0.97) and 0.82 (95% CI, 0.80-0.83) respectively.<h4>Conclusion</h4>GeneXpert vanA/vanB can diagnose VRE with high-accuracy and shows greater accuracy in diagnosing vanA.
format	article
author	Zhuo-Lei Li Qi-Bing Luo Shan-Shan Xiao Ze-Hong Lin Ye-Ling Liu Meng-Yi Han Jing-Hua Zhong Tian-Xing Ji Xu-Guang Guo
author_facet	Zhuo-Lei Li Qi-Bing Luo Shan-Shan Xiao Ze-Hong Lin Ye-Ling Liu Meng-Yi Han Jing-Hua Zhong Tian-Xing Ji Xu-Guang Guo
author_sort	Zhuo-Lei Li
title	Evaluation of GeneXpert vanA/vanB in the early diagnosis of vancomycin-resistant enterococci infection.
title_short	Evaluation of GeneXpert vanA/vanB in the early diagnosis of vancomycin-resistant enterococci infection.
title_full	Evaluation of GeneXpert vanA/vanB in the early diagnosis of vancomycin-resistant enterococci infection.
title_fullStr	Evaluation of GeneXpert vanA/vanB in the early diagnosis of vancomycin-resistant enterococci infection.
title_full_unstemmed	Evaluation of GeneXpert vanA/vanB in the early diagnosis of vancomycin-resistant enterococci infection.
title_sort	evaluation of genexpert vana/vanb in the early diagnosis of vancomycin-resistant enterococci infection.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/82f7eea1c9cc41118b74a68ba35a065e
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Evaluation of GeneXpert vanA/vanB in the early diagnosis of vancomycin-resistant enterococci infection.

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