Pharmacogenetics of hypoglycemic agents

Despite the increase in the number of hypoglycemic agents, 35%–40% of patients with diabetes are unable to achieve adequate glycemic control. One of the reasons is the genetic heterogeneity of diabetes mellitus, requiring different treatment approaches; however, the individual metabolic features and...

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Autores principales:	Irina Vladimirovna Kononenko, Aleksandr Yuryevich Mayorov, Ekaterina Olegovna Koksharova, Marina Vladimirovna Shestakova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2015
Materias:	diabetes mellitus pharmacogenetics hypoglycemic agents Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/82f953229ed34cbea404d841af9850cd
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id	oai:doaj.org-article:82f953229ed34cbea404d841af9850cd
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spelling	oai:doaj.org-article:82f953229ed34cbea404d841af9850cd2021-11-14T09:00:20ZPharmacogenetics of hypoglycemic agents2072-03512072-037810.14341/DM7681https://doaj.org/article/82f953229ed34cbea404d841af9850cd2015-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7681https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Despite the increase in the number of hypoglycemic agents, 35%–40% of patients with diabetes are unable to achieve adequate glycemic control. One of the reasons is the genetic heterogeneity of diabetes mellitus, requiring different treatment approaches; however, the individual metabolic features and sensitivity to drugs also affect the therapeutic effectiveness. The review presents the main results of pharmacogenetic research of several antidiabetic drugs: metformin, sulfonylurea, agonists of glucagon-like peptide-1 and thiazolidinediones.Irina Vladimirovna KononenkoAleksandr Yuryevich MayorovEkaterina Olegovna KoksharovaMarina Vladimirovna ShestakovaEndocrinology Research Centrearticlediabetes mellituspharmacogeneticshypoglycemic agentsNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 18, Iss 4, Pp 28-34 (2015)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus pharmacogenetics hypoglycemic agents Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus pharmacogenetics hypoglycemic agents Nutritional diseases. Deficiency diseases RC620-627 Irina Vladimirovna Kononenko Aleksandr Yuryevich Mayorov Ekaterina Olegovna Koksharova Marina Vladimirovna Shestakova Pharmacogenetics of hypoglycemic agents
description	Despite the increase in the number of hypoglycemic agents, 35%–40% of patients with diabetes are unable to achieve adequate glycemic control. One of the reasons is the genetic heterogeneity of diabetes mellitus, requiring different treatment approaches; however, the individual metabolic features and sensitivity to drugs also affect the therapeutic effectiveness. The review presents the main results of pharmacogenetic research of several antidiabetic drugs: metformin, sulfonylurea, agonists of glucagon-like peptide-1 and thiazolidinediones.
format	article
author	Irina Vladimirovna Kononenko Aleksandr Yuryevich Mayorov Ekaterina Olegovna Koksharova Marina Vladimirovna Shestakova
author_facet	Irina Vladimirovna Kononenko Aleksandr Yuryevich Mayorov Ekaterina Olegovna Koksharova Marina Vladimirovna Shestakova
author_sort	Irina Vladimirovna Kononenko
title	Pharmacogenetics of hypoglycemic agents
title_short	Pharmacogenetics of hypoglycemic agents
title_full	Pharmacogenetics of hypoglycemic agents
title_fullStr	Pharmacogenetics of hypoglycemic agents
title_full_unstemmed	Pharmacogenetics of hypoglycemic agents
title_sort	pharmacogenetics of hypoglycemic agents
publisher	Endocrinology Research Centre
publishDate	2015
url	https://doaj.org/article/82f953229ed34cbea404d841af9850cd
work_keys_str_mv	AT irinavladimirovnakononenko pharmacogeneticsofhypoglycemicagents AT aleksandryuryevichmayorov pharmacogeneticsofhypoglycemicagents AT ekaterinaolegovnakoksharova pharmacogeneticsofhypoglycemicagents AT marinavladimirovnashestakova pharmacogeneticsofhypoglycemicagents
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Pharmacogenetics of hypoglycemic agents

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