G6PD protects from oxidative damage and improves healthspan in mice

The enzyme G6PD generates the reductive metabolite NADPH, which has antioxidant effects, but has also been linked to tumour growth. Here the authors generate mice that modestly overexpress G6PD and report increased lifespan in females, and no negative effects on tumour formation in various genetic m...

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Autores principales:	Sandrina Nóbrega-Pereira, Pablo J. Fernandez-Marcos, Thomas Brioche, Mari Carmen Gomez-Cabrera, Andrea Salvador-Pascual, Juana M. Flores, Jose Viña, Manuel Serrano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/82fba91b5bae472ea2ba057c123a0b71
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spelling	oai:doaj.org-article:82fba91b5bae472ea2ba057c123a0b712021-12-02T17:32:36ZG6PD protects from oxidative damage and improves healthspan in mice10.1038/ncomms108942041-1723https://doaj.org/article/82fba91b5bae472ea2ba057c123a0b712016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10894https://doaj.org/toc/2041-1723The enzyme G6PD generates the reductive metabolite NADPH, which has antioxidant effects, but has also been linked to tumour growth. Here the authors generate mice that modestly overexpress G6PD and report increased lifespan in females, and no negative effects on tumour formation in various genetic models.Sandrina Nóbrega-PereiraPablo J. Fernandez-MarcosThomas BriocheMari Carmen Gomez-CabreraAndrea Salvador-PascualJuana M. FloresJose ViñaManuel SerranoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sandrina Nóbrega-Pereira Pablo J. Fernandez-Marcos Thomas Brioche Mari Carmen Gomez-Cabrera Andrea Salvador-Pascual Juana M. Flores Jose Viña Manuel Serrano G6PD protects from oxidative damage and improves healthspan in mice
description	The enzyme G6PD generates the reductive metabolite NADPH, which has antioxidant effects, but has also been linked to tumour growth. Here the authors generate mice that modestly overexpress G6PD and report increased lifespan in females, and no negative effects on tumour formation in various genetic models.
format	article
author	Sandrina Nóbrega-Pereira Pablo J. Fernandez-Marcos Thomas Brioche Mari Carmen Gomez-Cabrera Andrea Salvador-Pascual Juana M. Flores Jose Viña Manuel Serrano
author_facet	Sandrina Nóbrega-Pereira Pablo J. Fernandez-Marcos Thomas Brioche Mari Carmen Gomez-Cabrera Andrea Salvador-Pascual Juana M. Flores Jose Viña Manuel Serrano
author_sort	Sandrina Nóbrega-Pereira
title	G6PD protects from oxidative damage and improves healthspan in mice
title_short	G6PD protects from oxidative damage and improves healthspan in mice
title_full	G6PD protects from oxidative damage and improves healthspan in mice
title_fullStr	G6PD protects from oxidative damage and improves healthspan in mice
title_full_unstemmed	G6PD protects from oxidative damage and improves healthspan in mice
title_sort	g6pd protects from oxidative damage and improves healthspan in mice
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/82fba91b5bae472ea2ba057c123a0b71
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G6PD protects from oxidative damage and improves healthspan in mice

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