MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis

Axl is a TAM receptor that can inhibit Toll-like receptor (TLR) -induced pro-inflammatory production by dendritic cells (DC). Here the authors show that miR-34a targets Axl to control CD1c+ DC activity in mice, and that miR-34a-deficient mice are resistant to collagen-induced arthritis, whereas DCs...

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Autores principales:	Mariola Kurowska-Stolarska, Stefano Alivernini, Emma Garcia Melchor, Aziza Elmesmari, Barbara Tolusso, Clare Tange, Luca Petricca, Derek S. Gilchrist, Gabriele Di Sante, Chantal Keijzer, Lynn Stewart, Clara Di Mario, Vicky Morrison, James M. Brewer, Duncan Porter, Simon Milling, Ronald D. Baxter, David McCarey, Elisa Gremese, Greg Lemke, Gianfranco Ferraccioli, Charles McSharry, Iain B. McInnes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/82ffc64d997240fa87e18b12e513a829
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spelling	oai:doaj.org-article:82ffc64d997240fa87e18b12e513a8292021-12-02T14:40:45ZMicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis10.1038/ncomms158772041-1723https://doaj.org/article/82ffc64d997240fa87e18b12e513a8292017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15877https://doaj.org/toc/2041-1723Axl is a TAM receptor that can inhibit Toll-like receptor (TLR) -induced pro-inflammatory production by dendritic cells (DC). Here the authors show that miR-34a targets Axl to control CD1c+ DC activity in mice, and that miR-34a-deficient mice are resistant to collagen-induced arthritis, whereas DCs from patients with rheumatoid arthritis have high levels of miR- 34a.Mariola Kurowska-StolarskaStefano AliverniniEmma Garcia MelchorAziza ElmesmariBarbara TolussoClare TangeLuca PetriccaDerek S. GilchristGabriele Di SanteChantal KeijzerLynn StewartClara Di MarioVicky MorrisonJames M. BrewerDuncan PorterSimon MillingRonald D. BaxterDavid McCareyElisa GremeseGreg LemkeGianfranco FerraccioliCharles McSharryIain B. McInnesNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mariola Kurowska-Stolarska Stefano Alivernini Emma Garcia Melchor Aziza Elmesmari Barbara Tolusso Clare Tange Luca Petricca Derek S. Gilchrist Gabriele Di Sante Chantal Keijzer Lynn Stewart Clara Di Mario Vicky Morrison James M. Brewer Duncan Porter Simon Milling Ronald D. Baxter David McCarey Elisa Gremese Greg Lemke Gianfranco Ferraccioli Charles McSharry Iain B. McInnes MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis
description	Axl is a TAM receptor that can inhibit Toll-like receptor (TLR) -induced pro-inflammatory production by dendritic cells (DC). Here the authors show that miR-34a targets Axl to control CD1c+ DC activity in mice, and that miR-34a-deficient mice are resistant to collagen-induced arthritis, whereas DCs from patients with rheumatoid arthritis have high levels of miR- 34a.
format	article
author	Mariola Kurowska-Stolarska Stefano Alivernini Emma Garcia Melchor Aziza Elmesmari Barbara Tolusso Clare Tange Luca Petricca Derek S. Gilchrist Gabriele Di Sante Chantal Keijzer Lynn Stewart Clara Di Mario Vicky Morrison James M. Brewer Duncan Porter Simon Milling Ronald D. Baxter David McCarey Elisa Gremese Greg Lemke Gianfranco Ferraccioli Charles McSharry Iain B. McInnes
author_facet	Mariola Kurowska-Stolarska Stefano Alivernini Emma Garcia Melchor Aziza Elmesmari Barbara Tolusso Clare Tange Luca Petricca Derek S. Gilchrist Gabriele Di Sante Chantal Keijzer Lynn Stewart Clara Di Mario Vicky Morrison James M. Brewer Duncan Porter Simon Milling Ronald D. Baxter David McCarey Elisa Gremese Greg Lemke Gianfranco Ferraccioli Charles McSharry Iain B. McInnes
author_sort	Mariola Kurowska-Stolarska
title	MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis
title_short	MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis
title_full	MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis
title_fullStr	MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis
title_full_unstemmed	MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis
title_sort	microrna-34a dependent regulation of axl controls the activation of dendritic cells in inflammatory arthritis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/82ffc64d997240fa87e18b12e513a829
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MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis

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