MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis

MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis

Axl is a TAM receptor that can inhibit Toll-like receptor (TLR) -induced pro-inflammatory production by dendritic cells (DC). Here the authors show that miR-34a targets Axl to control CD1c+ DC activity in mice, and that miR-34a-deficient mice are resistant to collagen-induced arthritis, whereas DCs...

Full description

Saved in:
Bibliographic Details
Main Authors: Mariola Kurowska-Stolarska, Stefano Alivernini, Emma Garcia Melchor, Aziza Elmesmari, Barbara Tolusso, Clare Tange, Luca Petricca, Derek S. Gilchrist, Gabriele Di Sante, Chantal Keijzer, Lynn Stewart, Clara Di Mario, Vicky Morrison, James M. Brewer, Duncan Porter, Simon Milling, Ronald D. Baxter, David McCarey, Elisa Gremese, Greg Lemke, Gianfranco Ferraccioli, Charles McSharry, Iain B. McInnes
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Science
Q
Online Access:https://doaj.org/article/82ffc64d997240fa87e18b12e513a829
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/82ffc64d997240fa87e18b12e513a829

Similar Items