Ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome

Genes express multiple mRNA isoforms through alternative processing. Here the authors analyze ribosome profiling data with ORQAS (ORF quantification pipeline for alternative splicing) and report that 40–50% of the expressed mRNA isoforms are translated.

Guardado en:

Detalles Bibliográficos
Autores principales:	Marina Reixachs-Solé, Jorge Ruiz-Orera, M. Mar Albà, Eduardo Eyras
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8300914fcd7944f19456d74ca9806c68
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8300914fcd7944f19456d74ca9806c68
record_format	dspace
spelling	oai:doaj.org-article:8300914fcd7944f19456d74ca9806c682021-12-02T17:31:40ZRibosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome10.1038/s41467-020-15634-w2041-1723https://doaj.org/article/8300914fcd7944f19456d74ca9806c682020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15634-whttps://doaj.org/toc/2041-1723Genes express multiple mRNA isoforms through alternative processing. Here the authors analyze ribosome profiling data with ORQAS (ORF quantification pipeline for alternative splicing) and report that 40–50% of the expressed mRNA isoforms are translated.Marina Reixachs-SoléJorge Ruiz-OreraM. Mar AlbàEduardo EyrasNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marina Reixachs-Solé Jorge Ruiz-Orera M. Mar Albà Eduardo Eyras Ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome
description	Genes express multiple mRNA isoforms through alternative processing. Here the authors analyze ribosome profiling data with ORQAS (ORF quantification pipeline for alternative splicing) and report that 40–50% of the expressed mRNA isoforms are translated.
format	article
author	Marina Reixachs-Solé Jorge Ruiz-Orera M. Mar Albà Eduardo Eyras
author_facet	Marina Reixachs-Solé Jorge Ruiz-Orera M. Mar Albà Eduardo Eyras
author_sort	Marina Reixachs-Solé
title	Ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome
title_short	Ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome
title_full	Ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome
title_fullStr	Ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome
title_full_unstemmed	Ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome
title_sort	ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8300914fcd7944f19456d74ca9806c68
work_keys_str_mv	AT marinareixachssole ribosomeprofilingatisoformlevelrevealsevolutionaryconservedimpactsofdifferentialsplicingontheproteome AT jorgeruizorera ribosomeprofilingatisoformlevelrevealsevolutionaryconservedimpactsofdifferentialsplicingontheproteome AT mmaralba ribosomeprofilingatisoformlevelrevealsevolutionaryconservedimpactsofdifferentialsplicingontheproteome AT eduardoeyras ribosomeprofilingatisoformlevelrevealsevolutionaryconservedimpactsofdifferentialsplicingontheproteome
_version_	1718380563824377856

Ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome

Ejemplares similares