Association of ADRB2 gene polymorphism with dilated cardiomyopathy

Aim. To study the association of the rs1042713 polymorphism of the ADRB2 gene with cardiomyopathies of various origins. Material and methods. The study included patients with dilated cardiomyopathy (DCMP) and myocardial dilatation of ischemic genesis (DM IG).The total number of people surveyed is...

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Autores principales:	Svetlana Y. Nikulina, Оksana O. Kuznetsova, Anna A. Chernova, Gennadiy V. Matyushin, Anna A. Gurazheva, Vladimir N. Maksimov
Formato:	article
Lenguaje:	EN RU
Publicado:	Concilium Medicum 2021
Materias:	dilated cardiomyopathy genetic polymorphism dilatation of heart ischemic genesis adrb2 protein polymorphism rs1042713 heart failure genetic predisposition Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/830be702d41a4f939bf0f6c55b7fd0f9
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spelling	oai:doaj.org-article:830be702d41a4f939bf0f6c55b7fd0f92021-12-01T22:07:01ZAssociation of ADRB2 gene polymorphism with dilated cardiomyopathy2221-71852658-570710.26442/22217185.2021.1.200772https://doaj.org/article/830be702d41a4f939bf0f6c55b7fd0f92021-05-01T00:00:00Zhttps://cardiosomatics.orscience.ru/2221-7185/article/viewFile/71032/51884https://doaj.org/toc/2221-7185https://doaj.org/toc/2658-5707Aim. To study the association of the rs1042713 polymorphism of the ADRB2 gene with cardiomyopathies of various origins. Material and methods. The study included patients with dilated cardiomyopathy (DCMP) and myocardial dilatation of ischemic genesis (DM IG).The total number of people surveyed is 221. The average age of the subjects was 55.309.69 years. Patients were divided into 2 groups: one of them patients with a diagnosis of dilated cardiomyopathy idiopathic (predictors of expansion of the heart cavities are excluded) and the other-patients with dilated myocardium of ischemic origin (a history of IHD). The number of patients in the first group was 111, including 99 (89.2%) men and 12 (10.8%) women. The average age of patients in this group is 51.739.74 years. The second group included patients with myocardial dilatation of ischemic origin. Their number is 110 people, including 100 (91.5%) men and 10 (8.5%) women. The average age of the respondents is 58.688.38 years. The control group consists of individuals who did not have any manifestations of cardiovascular diseases. Their number is 221 people (average age 53.64.8 years). Laboratory and instrumental studies, coronary angiography, and molecular genetic studies of the rs1042713 polymorphism of the ADRB2 gene were performed for all participants in the study. Those patients who were excluded predictors of the occurrence of dilation of the heart cavities were assigned to the first group. The second group included patients with a history of CHD. Results. In the group with DCMP, 10.8% of patients were carriers of the common homozygous AA genotype, the heterozygous AG genotype 48.6%, and the rare homozygous GG genotype 40.5%. In the group of patients with DM IG, 16.4% of patients were carriers of the common homozygous AA genotype, the heterozygous AG genotype 51.8%, and the rare homozygous GG genotype 31.8%. In the control group, 11.8% of patients were identified as carriers of the homozygous genotype for the common allele, 47.5% carriers of the heterozygous genotype, and 40.7% carriers of the homozygous genotype for the rare allele. No statistically significant results were obtained in the group of patients with DCMP and DM IG compared to the control group of the rs1042713 polymorphism of the ADRB2 gene. Conclusion. No association of ADRB2 gene rs1042713 polymorphism with DCMI and DM IG was revealed.Svetlana Y. NikulinaОksana O. KuznetsovaAnna A. ChernovaGennadiy V. MatyushinAnna A. GurazhevaVladimir N. MaksimovConcilium Medicumarticledilated cardiomyopathygenetic polymorphismdilatation of heartischemic genesisadrb2 proteinpolymorphism rs1042713heart failuregenetic predispositionDiseases of the circulatory (Cardiovascular) systemRC666-701Diseases of the endocrine glands. Clinical endocrinologyRC648-665ENRUКардиоСоматика, Vol 12, Iss 1, Pp 28-33 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	dilated cardiomyopathy genetic polymorphism dilatation of heart ischemic genesis adrb2 protein polymorphism rs1042713 heart failure genetic predisposition Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	dilated cardiomyopathy genetic polymorphism dilatation of heart ischemic genesis adrb2 protein polymorphism rs1042713 heart failure genetic predisposition Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Svetlana Y. Nikulina Оksana O. Kuznetsova Anna A. Chernova Gennadiy V. Matyushin Anna A. Gurazheva Vladimir N. Maksimov Association of ADRB2 gene polymorphism with dilated cardiomyopathy
description	Aim. To study the association of the rs1042713 polymorphism of the ADRB2 gene with cardiomyopathies of various origins. Material and methods. The study included patients with dilated cardiomyopathy (DCMP) and myocardial dilatation of ischemic genesis (DM IG).The total number of people surveyed is 221. The average age of the subjects was 55.309.69 years. Patients were divided into 2 groups: one of them patients with a diagnosis of dilated cardiomyopathy idiopathic (predictors of expansion of the heart cavities are excluded) and the other-patients with dilated myocardium of ischemic origin (a history of IHD). The number of patients in the first group was 111, including 99 (89.2%) men and 12 (10.8%) women. The average age of patients in this group is 51.739.74 years. The second group included patients with myocardial dilatation of ischemic origin. Their number is 110 people, including 100 (91.5%) men and 10 (8.5%) women. The average age of the respondents is 58.688.38 years. The control group consists of individuals who did not have any manifestations of cardiovascular diseases. Their number is 221 people (average age 53.64.8 years). Laboratory and instrumental studies, coronary angiography, and molecular genetic studies of the rs1042713 polymorphism of the ADRB2 gene were performed for all participants in the study. Those patients who were excluded predictors of the occurrence of dilation of the heart cavities were assigned to the first group. The second group included patients with a history of CHD. Results. In the group with DCMP, 10.8% of patients were carriers of the common homozygous AA genotype, the heterozygous AG genotype 48.6%, and the rare homozygous GG genotype 40.5%. In the group of patients with DM IG, 16.4% of patients were carriers of the common homozygous AA genotype, the heterozygous AG genotype 51.8%, and the rare homozygous GG genotype 31.8%. In the control group, 11.8% of patients were identified as carriers of the homozygous genotype for the common allele, 47.5% carriers of the heterozygous genotype, and 40.7% carriers of the homozygous genotype for the rare allele. No statistically significant results were obtained in the group of patients with DCMP and DM IG compared to the control group of the rs1042713 polymorphism of the ADRB2 gene. Conclusion. No association of ADRB2 gene rs1042713 polymorphism with DCMI and DM IG was revealed.
format	article
author	Svetlana Y. Nikulina Оksana O. Kuznetsova Anna A. Chernova Gennadiy V. Matyushin Anna A. Gurazheva Vladimir N. Maksimov
author_facet	Svetlana Y. Nikulina Оksana O. Kuznetsova Anna A. Chernova Gennadiy V. Matyushin Anna A. Gurazheva Vladimir N. Maksimov
author_sort	Svetlana Y. Nikulina
title	Association of ADRB2 gene polymorphism with dilated cardiomyopathy
title_short	Association of ADRB2 gene polymorphism with dilated cardiomyopathy
title_full	Association of ADRB2 gene polymorphism with dilated cardiomyopathy
title_fullStr	Association of ADRB2 gene polymorphism with dilated cardiomyopathy
title_full_unstemmed	Association of ADRB2 gene polymorphism with dilated cardiomyopathy
title_sort	association of adrb2 gene polymorphism with dilated cardiomyopathy
publisher	Concilium Medicum
publishDate	2021
url	https://doaj.org/article/830be702d41a4f939bf0f6c55b7fd0f9
work_keys_str_mv	AT svetlanaynikulina associationofadrb2genepolymorphismwithdilatedcardiomyopathy AT oksanaokuznetsova associationofadrb2genepolymorphismwithdilatedcardiomyopathy AT annaachernova associationofadrb2genepolymorphismwithdilatedcardiomyopathy AT gennadiyvmatyushin associationofadrb2genepolymorphismwithdilatedcardiomyopathy AT annaagurazheva associationofadrb2genepolymorphismwithdilatedcardiomyopathy AT vladimirnmaksimov associationofadrb2genepolymorphismwithdilatedcardiomyopathy
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Association of ADRB2 gene polymorphism with dilated cardiomyopathy

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