Murid herpesvirus-4 exploits dendritic cells to infect B cells.

Dendritic cells (DCs) play a central role in initiating immune responses. Some persistent viruses infect DCs and can disrupt their functions in vitro. However, these viruses remain strongly immunogenic in vivo. Thus what role DC infection plays in the pathogenesis of persistent infections is unclear...

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Autores principales:	Miguel Gaspar, Janet S May, Soumi Sukla, Bruno Frederico, Michael B Gill, Christopher M Smith, Gabrielle T Belz, Philip G Stevenson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/830c8ca746b345b0b9ab1eb3ea162939
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spelling	oai:doaj.org-article:830c8ca746b345b0b9ab1eb3ea1629392021-11-18T06:05:09ZMurid herpesvirus-4 exploits dendritic cells to infect B cells.1553-73661553-737410.1371/journal.ppat.1002346https://doaj.org/article/830c8ca746b345b0b9ab1eb3ea1629392011-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22102809/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Dendritic cells (DCs) play a central role in initiating immune responses. Some persistent viruses infect DCs and can disrupt their functions in vitro. However, these viruses remain strongly immunogenic in vivo. Thus what role DC infection plays in the pathogenesis of persistent infections is unclear. Here we show that a persistent, B cell-tropic gamma-herpesvirus, Murid Herpesvirus-4 (MuHV-4), infects DCs early after host entry, before it establishes a substantial infection of B cells. DC-specific virus marking by cre-lox recombination revealed that a significant fraction of the virus latent in B cells had passed through a DC, and a virus attenuated for replication in DCs was impaired in B cell colonization. In vitro MuHV-4 dramatically altered the DC cytoskeleton, suggesting that it manipulates DC migration and shape in order to spread. MuHV-4 therefore uses DCs to colonize B cells.Miguel GasparJanet S MaySoumi SuklaBruno FredericoMichael B GillChristopher M SmithGabrielle T BelzPhilip G StevensonPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 7, Iss 11, p e1002346 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Miguel Gaspar Janet S May Soumi Sukla Bruno Frederico Michael B Gill Christopher M Smith Gabrielle T Belz Philip G Stevenson Murid herpesvirus-4 exploits dendritic cells to infect B cells.
description	Dendritic cells (DCs) play a central role in initiating immune responses. Some persistent viruses infect DCs and can disrupt their functions in vitro. However, these viruses remain strongly immunogenic in vivo. Thus what role DC infection plays in the pathogenesis of persistent infections is unclear. Here we show that a persistent, B cell-tropic gamma-herpesvirus, Murid Herpesvirus-4 (MuHV-4), infects DCs early after host entry, before it establishes a substantial infection of B cells. DC-specific virus marking by cre-lox recombination revealed that a significant fraction of the virus latent in B cells had passed through a DC, and a virus attenuated for replication in DCs was impaired in B cell colonization. In vitro MuHV-4 dramatically altered the DC cytoskeleton, suggesting that it manipulates DC migration and shape in order to spread. MuHV-4 therefore uses DCs to colonize B cells.
format	article
author	Miguel Gaspar Janet S May Soumi Sukla Bruno Frederico Michael B Gill Christopher M Smith Gabrielle T Belz Philip G Stevenson
author_facet	Miguel Gaspar Janet S May Soumi Sukla Bruno Frederico Michael B Gill Christopher M Smith Gabrielle T Belz Philip G Stevenson
author_sort	Miguel Gaspar
title	Murid herpesvirus-4 exploits dendritic cells to infect B cells.
title_short	Murid herpesvirus-4 exploits dendritic cells to infect B cells.
title_full	Murid herpesvirus-4 exploits dendritic cells to infect B cells.
title_fullStr	Murid herpesvirus-4 exploits dendritic cells to infect B cells.
title_full_unstemmed	Murid herpesvirus-4 exploits dendritic cells to infect B cells.
title_sort	murid herpesvirus-4 exploits dendritic cells to infect b cells.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/830c8ca746b345b0b9ab1eb3ea162939
work_keys_str_mv	AT miguelgaspar muridherpesvirus4exploitsdendriticcellstoinfectbcells AT janetsmay muridherpesvirus4exploitsdendriticcellstoinfectbcells AT soumisukla muridherpesvirus4exploitsdendriticcellstoinfectbcells AT brunofrederico muridherpesvirus4exploitsdendriticcellstoinfectbcells AT michaelbgill muridherpesvirus4exploitsdendriticcellstoinfectbcells AT christophermsmith muridherpesvirus4exploitsdendriticcellstoinfectbcells AT gabrielletbelz muridherpesvirus4exploitsdendriticcellstoinfectbcells AT philipgstevenson muridherpesvirus4exploitsdendriticcellstoinfectbcells
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Murid herpesvirus-4 exploits dendritic cells to infect B cells.

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