CD147 deficiency is associated with impairedsperm motility/acrosome reaction and offersa therapeutic target for asthenozoospermia

Patients with asthenozoospermia often present multiple defects in sperm functions apart from a decrease in sperm motility. However, the etiological factors underlying these multifaceted defects remain mostly unexplored, which may lead to unnecessary treatment and unsatisfactory assisted reproductive...

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Autores principales:	Hao Chen, Xiao Shi, Xiaofeng Li, Ruiying Diao, Qian Ma, Jing Jin, Zhuolin Qiu, Cailing Li, Mei Kuen Yu, Chaoqun Wang, Xianxin Li, Fanghong Li, David Yiu Leung Chan, Allan Zijian Zhao, Zhiming Cai, Fei Sun, Kin Lam Fok
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	asthenozoospermia CD147 sperm motility acrosome reaction calcium influx pregnancy outcome Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/830e08021c8f4238b8dbd27c232f6bba
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spelling	oai:doaj.org-article:830e08021c8f4238b8dbd27c232f6bba2021-11-24T04:28:45ZCD147 deficiency is associated with impairedsperm motility/acrosome reaction and offersa therapeutic target for asthenozoospermia2162-253110.1016/j.omtn.2021.11.009https://doaj.org/article/830e08021c8f4238b8dbd27c232f6bba2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2162253121002845https://doaj.org/toc/2162-2531Patients with asthenozoospermia often present multiple defects in sperm functions apart from a decrease in sperm motility. However, the etiological factors underlying these multifaceted defects remain mostly unexplored, which may lead to unnecessary treatment and unsatisfactory assisted reproductive technologies (ART) outcome. Here, we show that the protein levels of CD147 were lowered in sperm obtained from asthenozoospermic infertile patients exhibiting defects in both sperm motility and the acrosome reaction. Whereas CD147 maintained sperm motility before capacitation, female tract-derived soluble CD147 interacted with sperm-bound CD147 to induce an acrosome reaction in capacitated sperm. Soluble CD147 treatment restored the acrosome reaction and improved the fertility of sperm from patients with asthenozoospermia. Mechanistically, CD147 promotes sperm motility and acrosome reaction (AR) by eliciting Ca2+ influx through soluble CD147 binding to sperm-bound CD147. Notably, the level of soluble CD147 in seminal plasma was positively correlated with the fertilization rate and pregnancy outcome in infertile couples undergoing in vitro fertilization. Our study has identified a marker for the diagnosis and a therapeutic target for the defective AR capability in asthenozoospermia and a candidate for the prediction of in vitro fertilization outcomes for male infertile patients that facilitates the development of precision medicine in ART.Hao ChenXiao ShiXiaofeng LiRuiying DiaoQian MaJing JinZhuolin QiuCailing LiMei Kuen YuChaoqun WangXianxin LiFanghong LiDavid Yiu Leung ChanAllan Zijian ZhaoZhiming CaiFei SunKin Lam FokElsevierarticleasthenozoospermiaCD147sperm motilityacrosome reactioncalcium influxpregnancy outcomeTherapeutics. PharmacologyRM1-950ENMolecular Therapy: Nucleic Acids, Vol 26, Iss , Pp 1374-1386 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	asthenozoospermia CD147 sperm motility acrosome reaction calcium influx pregnancy outcome Therapeutics. Pharmacology RM1-950
spellingShingle	asthenozoospermia CD147 sperm motility acrosome reaction calcium influx pregnancy outcome Therapeutics. Pharmacology RM1-950 Hao Chen Xiao Shi Xiaofeng Li Ruiying Diao Qian Ma Jing Jin Zhuolin Qiu Cailing Li Mei Kuen Yu Chaoqun Wang Xianxin Li Fanghong Li David Yiu Leung Chan Allan Zijian Zhao Zhiming Cai Fei Sun Kin Lam Fok CD147 deficiency is associated with impairedsperm motility/acrosome reaction and offersa therapeutic target for asthenozoospermia
description	Patients with asthenozoospermia often present multiple defects in sperm functions apart from a decrease in sperm motility. However, the etiological factors underlying these multifaceted defects remain mostly unexplored, which may lead to unnecessary treatment and unsatisfactory assisted reproductive technologies (ART) outcome. Here, we show that the protein levels of CD147 were lowered in sperm obtained from asthenozoospermic infertile patients exhibiting defects in both sperm motility and the acrosome reaction. Whereas CD147 maintained sperm motility before capacitation, female tract-derived soluble CD147 interacted with sperm-bound CD147 to induce an acrosome reaction in capacitated sperm. Soluble CD147 treatment restored the acrosome reaction and improved the fertility of sperm from patients with asthenozoospermia. Mechanistically, CD147 promotes sperm motility and acrosome reaction (AR) by eliciting Ca2+ influx through soluble CD147 binding to sperm-bound CD147. Notably, the level of soluble CD147 in seminal plasma was positively correlated with the fertilization rate and pregnancy outcome in infertile couples undergoing in vitro fertilization. Our study has identified a marker for the diagnosis and a therapeutic target for the defective AR capability in asthenozoospermia and a candidate for the prediction of in vitro fertilization outcomes for male infertile patients that facilitates the development of precision medicine in ART.
format	article
author	Hao Chen Xiao Shi Xiaofeng Li Ruiying Diao Qian Ma Jing Jin Zhuolin Qiu Cailing Li Mei Kuen Yu Chaoqun Wang Xianxin Li Fanghong Li David Yiu Leung Chan Allan Zijian Zhao Zhiming Cai Fei Sun Kin Lam Fok
author_facet	Hao Chen Xiao Shi Xiaofeng Li Ruiying Diao Qian Ma Jing Jin Zhuolin Qiu Cailing Li Mei Kuen Yu Chaoqun Wang Xianxin Li Fanghong Li David Yiu Leung Chan Allan Zijian Zhao Zhiming Cai Fei Sun Kin Lam Fok
author_sort	Hao Chen
title	CD147 deficiency is associated with impairedsperm motility/acrosome reaction and offersa therapeutic target for asthenozoospermia
title_short	CD147 deficiency is associated with impairedsperm motility/acrosome reaction and offersa therapeutic target for asthenozoospermia
title_full	CD147 deficiency is associated with impairedsperm motility/acrosome reaction and offersa therapeutic target for asthenozoospermia
title_fullStr	CD147 deficiency is associated with impairedsperm motility/acrosome reaction and offersa therapeutic target for asthenozoospermia
title_full_unstemmed	CD147 deficiency is associated with impairedsperm motility/acrosome reaction and offersa therapeutic target for asthenozoospermia
title_sort	cd147 deficiency is associated with impairedsperm motility/acrosome reaction and offersa therapeutic target for asthenozoospermia
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/830e08021c8f4238b8dbd27c232f6bba
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CD147 deficiency is associated with impairedsperm motility/acrosome reaction and offersa therapeutic target for asthenozoospermia

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