RNAi Crop Protection Advances

RNAi technology is a versatile, effective, safe, and eco-friendly alternative for crop protection. There is plenty of evidence of its use through host-induced gene silencing (HIGS) and emerging evidence that spray-induced gene silencing (SIGS) techniques can work as well to control viruses, bacteria...

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Autores principales:	Alejandro Hernández-Soto, Randall Chacón-Cerdas
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	RNAi dsRNA silencing encapsulation liposomes virus-like particles Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/8311a5cab99042839b67b02eb46f9553
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spelling	oai:doaj.org-article:8311a5cab99042839b67b02eb46f95532021-11-25T17:53:48ZRNAi Crop Protection Advances10.3390/ijms2222121481422-00671661-6596https://doaj.org/article/8311a5cab99042839b67b02eb46f95532021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12148https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067RNAi technology is a versatile, effective, safe, and eco-friendly alternative for crop protection. There is plenty of evidence of its use through host-induced gene silencing (HIGS) and emerging evidence that spray-induced gene silencing (SIGS) techniques can work as well to control viruses, bacteria, fungi, insects, and nematodes. For SIGS, its most significant challenge is achieving stability and avoiding premature degradation of RNAi in the environment or during its absorption by the target organism. One alternative is encapsulation in liposomes, virus-like particles, polyplex nanoparticles, and bioclay, which can be obtained through the recombinant production of RNAi in vectors, transgenesis, and micro/nanoencapsulation. The materials must be safe, biodegradable, and stable in multiple chemical environments, favoring the controlled release of RNAi. Most of the current research on encapsulated RNAi focuses primarily on oral delivery to control insects by silencing essential genes. The regulation of RNAi technology focuses on risk assessment using different approaches; however, this technology has positive economic, environmental, and human health implications for its use in agriculture. The emergence of alternatives combining RNAi gene silencing with the induction of resistance in crops by elicitation and metabolic control is expected, as well as multiple silencing and biotechnological optimization of its large-scale production.Alejandro Hernández-SotoRandall Chacón-CerdasMDPI AGarticleRNAidsRNAsilencingencapsulationliposomesvirus-like particlesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12148, p 12148 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	RNAi dsRNA silencing encapsulation liposomes virus-like particles Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	RNAi dsRNA silencing encapsulation liposomes virus-like particles Biology (General) QH301-705.5 Chemistry QD1-999 Alejandro Hernández-Soto Randall Chacón-Cerdas RNAi Crop Protection Advances
description	RNAi technology is a versatile, effective, safe, and eco-friendly alternative for crop protection. There is plenty of evidence of its use through host-induced gene silencing (HIGS) and emerging evidence that spray-induced gene silencing (SIGS) techniques can work as well to control viruses, bacteria, fungi, insects, and nematodes. For SIGS, its most significant challenge is achieving stability and avoiding premature degradation of RNAi in the environment or during its absorption by the target organism. One alternative is encapsulation in liposomes, virus-like particles, polyplex nanoparticles, and bioclay, which can be obtained through the recombinant production of RNAi in vectors, transgenesis, and micro/nanoencapsulation. The materials must be safe, biodegradable, and stable in multiple chemical environments, favoring the controlled release of RNAi. Most of the current research on encapsulated RNAi focuses primarily on oral delivery to control insects by silencing essential genes. The regulation of RNAi technology focuses on risk assessment using different approaches; however, this technology has positive economic, environmental, and human health implications for its use in agriculture. The emergence of alternatives combining RNAi gene silencing with the induction of resistance in crops by elicitation and metabolic control is expected, as well as multiple silencing and biotechnological optimization of its large-scale production.
format	article
author	Alejandro Hernández-Soto Randall Chacón-Cerdas
author_facet	Alejandro Hernández-Soto Randall Chacón-Cerdas
author_sort	Alejandro Hernández-Soto
title	RNAi Crop Protection Advances
title_short	RNAi Crop Protection Advances
title_full	RNAi Crop Protection Advances
title_fullStr	RNAi Crop Protection Advances
title_full_unstemmed	RNAi Crop Protection Advances
title_sort	rnai crop protection advances
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8311a5cab99042839b67b02eb46f9553
work_keys_str_mv	AT alejandrohernandezsoto rnaicropprotectionadvances AT randallchaconcerdas rnaicropprotectionadvances
_version_	1718411871732629504

RNAi Crop Protection Advances

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