High risk cutaneous squamous cell carcinoma of the head and neck

The majority of patients with head and neck cutaneous squamous cell carcinoma (cSCC) are successfully treated with surgical treatment of the primary site. While only a minority of patients is at risk for regional metastasis, these patients have significantly worse outcomes. Tumor and patient factors...

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Autores principales:	Stephen Y. Kang, Amanda E. Toland
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2016
Materias:	Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/8312bec14a6c42198e11bbc7c4e0a448
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spelling	oai:doaj.org-article:8312bec14a6c42198e11bbc7c4e0a4482021-12-02T12:55:41ZHigh risk cutaneous squamous cell carcinoma of the head and neck2095-881110.1016/j.wjorl.2016.05.004https://doaj.org/article/8312bec14a6c42198e11bbc7c4e0a4482016-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881116300208https://doaj.org/toc/2095-8811The majority of patients with head and neck cutaneous squamous cell carcinoma (cSCC) are successfully treated with surgical treatment of the primary site. While only a minority of patients is at risk for regional metastasis, these patients have significantly worse outcomes. Tumor and patient factors that place patients at high risk for development of regional metastasis have been identified. Advancing treatment of cSCC requires identifying and escalating treatment in this high risk patient population, while avoiding overtreatment of the majority of cSCC patients that do not develop regional metastasis. Sentinel lymph node biopsy has emerged as a promising technique in cSCC to detect micrometastasis and allow early surgical treatment of regional disease. Future directions involve genomic characterization of metastatic and nonmetastatic cSCC to identify genomic alterations causing metastasis that may be used to predict disease behavior. Keywords: Squamous cell carcinoma, Cutaneous, Head and neck cancerStephen Y. KangAmanda E. TolandKeAi Communications Co., Ltd.articleOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 2, Iss 2, Pp 136-140 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Otorhinolaryngology RF1-547 Surgery RD1-811 Stephen Y. Kang Amanda E. Toland High risk cutaneous squamous cell carcinoma of the head and neck
description	The majority of patients with head and neck cutaneous squamous cell carcinoma (cSCC) are successfully treated with surgical treatment of the primary site. While only a minority of patients is at risk for regional metastasis, these patients have significantly worse outcomes. Tumor and patient factors that place patients at high risk for development of regional metastasis have been identified. Advancing treatment of cSCC requires identifying and escalating treatment in this high risk patient population, while avoiding overtreatment of the majority of cSCC patients that do not develop regional metastasis. Sentinel lymph node biopsy has emerged as a promising technique in cSCC to detect micrometastasis and allow early surgical treatment of regional disease. Future directions involve genomic characterization of metastatic and nonmetastatic cSCC to identify genomic alterations causing metastasis that may be used to predict disease behavior. Keywords: Squamous cell carcinoma, Cutaneous, Head and neck cancer
format	article
author	Stephen Y. Kang Amanda E. Toland
author_facet	Stephen Y. Kang Amanda E. Toland
author_sort	Stephen Y. Kang
title	High risk cutaneous squamous cell carcinoma of the head and neck
title_short	High risk cutaneous squamous cell carcinoma of the head and neck
title_full	High risk cutaneous squamous cell carcinoma of the head and neck
title_fullStr	High risk cutaneous squamous cell carcinoma of the head and neck
title_full_unstemmed	High risk cutaneous squamous cell carcinoma of the head and neck
title_sort	high risk cutaneous squamous cell carcinoma of the head and neck
publisher	KeAi Communications Co., Ltd.
publishDate	2016
url	https://doaj.org/article/8312bec14a6c42198e11bbc7c4e0a448
work_keys_str_mv	AT stephenykang highriskcutaneoussquamouscellcarcinomaoftheheadandneck AT amandaetoland highriskcutaneoussquamouscellcarcinomaoftheheadandneck
_version_	1718393576591720448

High risk cutaneous squamous cell carcinoma of the head and neck

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