Application of Stem Cell-Derived Extracellular Vesicles as an Innovative Theranostics in Microbial Diseases

Extracellular vesicles (EVs), as nano-/micro-scale vehicles, are membranous particles containing various cargoes including peptides, proteins, different types of RNAs and other nucleic acids, and lipids. These vesicles are produced by all cell types, in which stem cells are a potent source for them....

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Autores principales:	Hani Keshavarz Alikhani, Bahare Shokoohian, Sama Rezasoltani, Nikoo Hossein-khannazer, Abbas Yadegar, Moustapha Hassan, Massoud Vosough
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	stem cells infectious disease antimicrobial agents bacterial EVs Viral EVs MSC-derived EVs Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/8313041e059a4a91ada027d8e3671b1f
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spelling	oai:doaj.org-article:8313041e059a4a91ada027d8e3671b1f2021-12-01T19:09:54ZApplication of Stem Cell-Derived Extracellular Vesicles as an Innovative Theranostics in Microbial Diseases1664-302X10.3389/fmicb.2021.785856https://doaj.org/article/8313041e059a4a91ada027d8e3671b1f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.785856/fullhttps://doaj.org/toc/1664-302XExtracellular vesicles (EVs), as nano-/micro-scale vehicles, are membranous particles containing various cargoes including peptides, proteins, different types of RNAs and other nucleic acids, and lipids. These vesicles are produced by all cell types, in which stem cells are a potent source for them. Stem cell-derived EVs could be promising platforms for treatment of infectious diseases and early diagnosis. Infectious diseases are responsible for more than 11 million deaths annually. Highly transmissible nature of some microbes, such as newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), drives researcher’s interest to set up different strategies to develop novel therapeutic strategies. Recently, EVs-based diagnostic and therapeutic approaches have been launched and gaining momentum very fast. The efficiency of stem cell-derived EVs on treatment of clinical complications of different viruses and bacteria, such as SARS-CoV-2, hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), Staphylococcus aureus, Escherichia coli has been demonstrated. On the other hand, microbial pathogens are able to incorporate their components into their EVs. The microbe-derived EVs have different physiological and pathological impacts on the other organisms. In this review, we briefly discussed biogenesis and the fate of EVs. Then, EV-based therapy was described and recent developments in understanding the potential application of stem cell-derived EVs on pathogenic microorganisms were recapitulated. Furthermore, the mechanisms by which EVs were exploited to fight against infectious diseases were highlighted. Finally, the deriver challenges in translation of stem cell-derived EVs into the clinical arena were explored.Hani Keshavarz AlikhaniBahare ShokoohianSama RezasoltaniNikoo Hossein-khannazerAbbas YadegarMoustapha HassanMassoud VosoughMassoud VosoughFrontiers Media S.A.articlestem cellsinfectious diseaseantimicrobial agentsbacterial EVsViral EVsMSC-derived EVsMicrobiologyQR1-502ENFrontiers in Microbiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stem cells infectious disease antimicrobial agents bacterial EVs Viral EVs MSC-derived EVs Microbiology QR1-502
spellingShingle	stem cells infectious disease antimicrobial agents bacterial EVs Viral EVs MSC-derived EVs Microbiology QR1-502 Hani Keshavarz Alikhani Bahare Shokoohian Sama Rezasoltani Nikoo Hossein-khannazer Abbas Yadegar Moustapha Hassan Massoud Vosough Massoud Vosough Application of Stem Cell-Derived Extracellular Vesicles as an Innovative Theranostics in Microbial Diseases
description	Extracellular vesicles (EVs), as nano-/micro-scale vehicles, are membranous particles containing various cargoes including peptides, proteins, different types of RNAs and other nucleic acids, and lipids. These vesicles are produced by all cell types, in which stem cells are a potent source for them. Stem cell-derived EVs could be promising platforms for treatment of infectious diseases and early diagnosis. Infectious diseases are responsible for more than 11 million deaths annually. Highly transmissible nature of some microbes, such as newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), drives researcher’s interest to set up different strategies to develop novel therapeutic strategies. Recently, EVs-based diagnostic and therapeutic approaches have been launched and gaining momentum very fast. The efficiency of stem cell-derived EVs on treatment of clinical complications of different viruses and bacteria, such as SARS-CoV-2, hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), Staphylococcus aureus, Escherichia coli has been demonstrated. On the other hand, microbial pathogens are able to incorporate their components into their EVs. The microbe-derived EVs have different physiological and pathological impacts on the other organisms. In this review, we briefly discussed biogenesis and the fate of EVs. Then, EV-based therapy was described and recent developments in understanding the potential application of stem cell-derived EVs on pathogenic microorganisms were recapitulated. Furthermore, the mechanisms by which EVs were exploited to fight against infectious diseases were highlighted. Finally, the deriver challenges in translation of stem cell-derived EVs into the clinical arena were explored.
format	article
author	Hani Keshavarz Alikhani Bahare Shokoohian Sama Rezasoltani Nikoo Hossein-khannazer Abbas Yadegar Moustapha Hassan Massoud Vosough Massoud Vosough
author_facet	Hani Keshavarz Alikhani Bahare Shokoohian Sama Rezasoltani Nikoo Hossein-khannazer Abbas Yadegar Moustapha Hassan Massoud Vosough Massoud Vosough
author_sort	Hani Keshavarz Alikhani
title	Application of Stem Cell-Derived Extracellular Vesicles as an Innovative Theranostics in Microbial Diseases
title_short	Application of Stem Cell-Derived Extracellular Vesicles as an Innovative Theranostics in Microbial Diseases
title_full	Application of Stem Cell-Derived Extracellular Vesicles as an Innovative Theranostics in Microbial Diseases
title_fullStr	Application of Stem Cell-Derived Extracellular Vesicles as an Innovative Theranostics in Microbial Diseases
title_full_unstemmed	Application of Stem Cell-Derived Extracellular Vesicles as an Innovative Theranostics in Microbial Diseases
title_sort	application of stem cell-derived extracellular vesicles as an innovative theranostics in microbial diseases
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8313041e059a4a91ada027d8e3671b1f
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Application of Stem Cell-Derived Extracellular Vesicles as an Innovative Theranostics in Microbial Diseases

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