HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity

HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity

RIG-I is a critical receptor in the induction of innate immune responses, but mutations in RIG-I can be associated with hyperactive signalling and autoimmune disease. Here Zheng et al. apply HDX-MS approaches to reveal dysregulated checkpoints that result in recognition of self-derived RNA during RI...

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Bibliographic Details
Main Authors: Jie Zheng, Chen Wang, Mi Ra Chang, Swapnil C. Devarkar, Brandon Schweibenz, Gogce C. Crynen, Ruben D. Garcia-Ordonez, Bruce D. Pascal, Scott J. Novick, Smita S. Patel, Joseph Marcotrigiano, Patrick R. Griffin
Format: article
Language:EN
Published: Nature Portfolio 2018
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Science
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Online Access:https://doaj.org/article/8317c8b61e4844eb852d67a0ef3d5f02
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Summary:RIG-I is a critical receptor in the induction of innate immune responses, but mutations in RIG-I can be associated with hyperactive signalling and autoimmune disease. Here Zheng et al. apply HDX-MS approaches to reveal dysregulated checkpoints that result in recognition of self-derived RNA during RIG-I mediated autoimmunity.

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