HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity

RIG-I is a critical receptor in the induction of innate immune responses, but mutations in RIG-I can be associated with hyperactive signalling and autoimmune disease. Here Zheng et al. apply HDX-MS approaches to reveal dysregulated checkpoints that result in recognition of self-derived RNA during RI...

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Autores principales:	Jie Zheng, Chen Wang, Mi Ra Chang, Swapnil C. Devarkar, Brandon Schweibenz, Gogce C. Crynen, Ruben D. Garcia-Ordonez, Bruce D. Pascal, Scott J. Novick, Smita S. Patel, Joseph Marcotrigiano, Patrick R. Griffin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8317c8b61e4844eb852d67a0ef3d5f02
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spelling	oai:doaj.org-article:8317c8b61e4844eb852d67a0ef3d5f022021-12-02T16:50:08ZHDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity10.1038/s41467-018-07780-z2041-1723https://doaj.org/article/8317c8b61e4844eb852d67a0ef3d5f022018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07780-zhttps://doaj.org/toc/2041-1723RIG-I is a critical receptor in the induction of innate immune responses, but mutations in RIG-I can be associated with hyperactive signalling and autoimmune disease. Here Zheng et al. apply HDX-MS approaches to reveal dysregulated checkpoints that result in recognition of self-derived RNA during RIG-I mediated autoimmunity.Jie ZhengChen WangMi Ra ChangSwapnil C. DevarkarBrandon SchweibenzGogce C. CrynenRuben D. Garcia-OrdonezBruce D. PascalScott J. NovickSmita S. PatelJoseph MarcotrigianoPatrick R. GriffinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jie Zheng Chen Wang Mi Ra Chang Swapnil C. Devarkar Brandon Schweibenz Gogce C. Crynen Ruben D. Garcia-Ordonez Bruce D. Pascal Scott J. Novick Smita S. Patel Joseph Marcotrigiano Patrick R. Griffin HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity
description	RIG-I is a critical receptor in the induction of innate immune responses, but mutations in RIG-I can be associated with hyperactive signalling and autoimmune disease. Here Zheng et al. apply HDX-MS approaches to reveal dysregulated checkpoints that result in recognition of self-derived RNA during RIG-I mediated autoimmunity.
format	article
author	Jie Zheng Chen Wang Mi Ra Chang Swapnil C. Devarkar Brandon Schweibenz Gogce C. Crynen Ruben D. Garcia-Ordonez Bruce D. Pascal Scott J. Novick Smita S. Patel Joseph Marcotrigiano Patrick R. Griffin
author_facet	Jie Zheng Chen Wang Mi Ra Chang Swapnil C. Devarkar Brandon Schweibenz Gogce C. Crynen Ruben D. Garcia-Ordonez Bruce D. Pascal Scott J. Novick Smita S. Patel Joseph Marcotrigiano Patrick R. Griffin
author_sort	Jie Zheng
title	HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity
title_short	HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity
title_full	HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity
title_fullStr	HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity
title_full_unstemmed	HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity
title_sort	hdx-ms reveals dysregulated checkpoints that compromise discrimination against self rna during rig-i mediated autoimmunity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8317c8b61e4844eb852d67a0ef3d5f02
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HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity

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