Pachychoroid disease and its association with retinal vein occlusion: a case–control study

Abstract The development of a retinal vein occlusion (RVO) is multifactorial. This study investigates pachychoroid as a risk factor for RVO or as an entity sharing common pathophysiology with RVO. A database screening at the University Eye Hospital, Ludwig-Maximilian University Munich, Germany was p...

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Autores principales:	Leonie F. Keidel, Sarah Zwingelberg, Benedikt Schworm, Nikolaus Luft, Tina Herold, Siegfried G. Priglinger, Jakob Siedlecki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/831b7ccb1c5f4d72988ba4175105cdd5
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spelling	oai:doaj.org-article:831b7ccb1c5f4d72988ba4175105cdd52021-12-02T19:16:18ZPachychoroid disease and its association with retinal vein occlusion: a case–control study10.1038/s41598-021-99115-02045-2322https://doaj.org/article/831b7ccb1c5f4d72988ba4175105cdd52021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99115-0https://doaj.org/toc/2045-2322Abstract The development of a retinal vein occlusion (RVO) is multifactorial. This study investigates pachychoroid as a risk factor for RVO or as an entity sharing common pathophysiology with RVO. A database screening at the University Eye Hospital, Ludwig-Maximilian University Munich, Germany was performed for patients diagnosed with central or branch RVO (CRVO/BRVO). In every patient a complete ophthalmologic examination was performed, including posterior segment enhanced depth spectral domain optical coherence tomography (EDI-SD-OCT). The SD-OCT scans of respective partner eyes without history of RVO were compared to an age- and refraction-matched, randomly recruited normal control group. In total, 312 eyes of 312 patients were included in this study, with 162 eyes in the RVO and 150 eyes in the control group. A significantly higher subfoveal choroidal thickness (SFCT) was found in the RVO (310.3 ± 72.5 (94 to 583) µm) as compared to the control group (237.0 ± 99.0 (62 to 498); p < 0.00001). Moreover, the RVO group showed a significantly higher prevalence of a symptomatic pachychoroid (22 vs. 9 eyes; odds ratio: 2.46; 95 CI: 1.10 to 5.53; p = 0.029). Since pachychoroid disease represents a bilateral entity, it might be a risk factor for RVO, or share risk factors with RVO.Leonie F. KeidelSarah ZwingelbergBenedikt SchwormNikolaus LuftTina HeroldSiegfried G. PriglingerJakob SiedleckiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leonie F. Keidel Sarah Zwingelberg Benedikt Schworm Nikolaus Luft Tina Herold Siegfried G. Priglinger Jakob Siedlecki Pachychoroid disease and its association with retinal vein occlusion: a case–control study
description	Abstract The development of a retinal vein occlusion (RVO) is multifactorial. This study investigates pachychoroid as a risk factor for RVO or as an entity sharing common pathophysiology with RVO. A database screening at the University Eye Hospital, Ludwig-Maximilian University Munich, Germany was performed for patients diagnosed with central or branch RVO (CRVO/BRVO). In every patient a complete ophthalmologic examination was performed, including posterior segment enhanced depth spectral domain optical coherence tomography (EDI-SD-OCT). The SD-OCT scans of respective partner eyes without history of RVO were compared to an age- and refraction-matched, randomly recruited normal control group. In total, 312 eyes of 312 patients were included in this study, with 162 eyes in the RVO and 150 eyes in the control group. A significantly higher subfoveal choroidal thickness (SFCT) was found in the RVO (310.3 ± 72.5 (94 to 583) µm) as compared to the control group (237.0 ± 99.0 (62 to 498); p < 0.00001). Moreover, the RVO group showed a significantly higher prevalence of a symptomatic pachychoroid (22 vs. 9 eyes; odds ratio: 2.46; 95 CI: 1.10 to 5.53; p = 0.029). Since pachychoroid disease represents a bilateral entity, it might be a risk factor for RVO, or share risk factors with RVO.
format	article
author	Leonie F. Keidel Sarah Zwingelberg Benedikt Schworm Nikolaus Luft Tina Herold Siegfried G. Priglinger Jakob Siedlecki
author_facet	Leonie F. Keidel Sarah Zwingelberg Benedikt Schworm Nikolaus Luft Tina Herold Siegfried G. Priglinger Jakob Siedlecki
author_sort	Leonie F. Keidel
title	Pachychoroid disease and its association with retinal vein occlusion: a case–control study
title_short	Pachychoroid disease and its association with retinal vein occlusion: a case–control study
title_full	Pachychoroid disease and its association with retinal vein occlusion: a case–control study
title_fullStr	Pachychoroid disease and its association with retinal vein occlusion: a case–control study
title_full_unstemmed	Pachychoroid disease and its association with retinal vein occlusion: a case–control study
title_sort	pachychoroid disease and its association with retinal vein occlusion: a case–control study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/831b7ccb1c5f4d72988ba4175105cdd5
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Pachychoroid disease and its association with retinal vein occlusion: a case–control study

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