N-glycosylation enables high lateral mobility of GPI-anchored proteins at a molecular crowding threshold

How molecular crowding affects membrane protein diffusion and function is not known. Here the authors measure diffusion of variant surface glycoprotein on trypanosomes and discover a molecular crowding threshold that limits diffusion, and find that N-linked glycans help to prevent retarding intermol...

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Autores principales:	Andreas J. W. Hartel, Marius Glogger, Nicola G. Jones, Wasim Abuillan, Christopher Batram, Anne Hermann, Susanne F. Fenz, Motomu Tanaka, Markus Engstler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/831b8d33c8d54ce4a633cf358d818285
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spelling	oai:doaj.org-article:831b8d33c8d54ce4a633cf358d8182852021-12-02T17:32:38ZN-glycosylation enables high lateral mobility of GPI-anchored proteins at a molecular crowding threshold10.1038/ncomms128702041-1723https://doaj.org/article/831b8d33c8d54ce4a633cf358d8182852016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12870https://doaj.org/toc/2041-1723How molecular crowding affects membrane protein diffusion and function is not known. Here the authors measure diffusion of variant surface glycoprotein on trypanosomes and discover a molecular crowding threshold that limits diffusion, and find that N-linked glycans help to prevent retarding intermolecular interactions.Andreas J. W. HartelMarius GloggerNicola G. JonesWasim AbuillanChristopher BatramAnne HermannSusanne F. FenzMotomu TanakaMarkus EngstlerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andreas J. W. Hartel Marius Glogger Nicola G. Jones Wasim Abuillan Christopher Batram Anne Hermann Susanne F. Fenz Motomu Tanaka Markus Engstler N-glycosylation enables high lateral mobility of GPI-anchored proteins at a molecular crowding threshold
description	How molecular crowding affects membrane protein diffusion and function is not known. Here the authors measure diffusion of variant surface glycoprotein on trypanosomes and discover a molecular crowding threshold that limits diffusion, and find that N-linked glycans help to prevent retarding intermolecular interactions.
format	article
author	Andreas J. W. Hartel Marius Glogger Nicola G. Jones Wasim Abuillan Christopher Batram Anne Hermann Susanne F. Fenz Motomu Tanaka Markus Engstler
author_facet	Andreas J. W. Hartel Marius Glogger Nicola G. Jones Wasim Abuillan Christopher Batram Anne Hermann Susanne F. Fenz Motomu Tanaka Markus Engstler
author_sort	Andreas J. W. Hartel
title	N-glycosylation enables high lateral mobility of GPI-anchored proteins at a molecular crowding threshold
title_short	N-glycosylation enables high lateral mobility of GPI-anchored proteins at a molecular crowding threshold
title_full	N-glycosylation enables high lateral mobility of GPI-anchored proteins at a molecular crowding threshold
title_fullStr	N-glycosylation enables high lateral mobility of GPI-anchored proteins at a molecular crowding threshold
title_full_unstemmed	N-glycosylation enables high lateral mobility of GPI-anchored proteins at a molecular crowding threshold
title_sort	n-glycosylation enables high lateral mobility of gpi-anchored proteins at a molecular crowding threshold
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/831b8d33c8d54ce4a633cf358d818285
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N-glycosylation enables high lateral mobility of GPI-anchored proteins at a molecular crowding threshold

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