ROLE OF CYTOKINE PRODUCTION DISORDERS IN GENESIS OF PLACENTAL INSUFFICIENCY AND EARLY REPRODUCTIVE LOSSES

We have analyzed clinical and laboratory data for 256 women surveyed in early pregnancy, being later classified by their pregnancy outcomes, i.e., placental insufficiency (n=106), interruption in the first trimester (n = 38) and uncomplicated cases with delivery of live, full-term infants (n = 112)....

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Autores principales:	I. A. Gazieva, G. N. Chistyakova, I. I. Remizova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2015
Materias:	cytokine production first trimester of pregnancy placental insufficiency early reproductive losses Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/831c093d7275425aaa9084535bd9ed5e
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spelling	oai:doaj.org-article:831c093d7275425aaa9084535bd9ed5e2021-11-18T08:03:44ZROLE OF CYTOKINE PRODUCTION DISORDERS IN GENESIS OF PLACENTAL INSUFFICIENCY AND EARLY REPRODUCTIVE LOSSES1563-06252313-741X10.15789/1563-0625-2014-6-539-550https://doaj.org/article/831c093d7275425aaa9084535bd9ed5e2015-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/766https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XWe have analyzed clinical and laboratory data for 256 women surveyed in early pregnancy, being later classified by their pregnancy outcomes, i.e., placental insufficiency (n=106), interruption in the first trimester (n = 38) and uncomplicated cases with delivery of live, full-term infants (n = 112). We evaluated serum levels of cytokines and their soluble receptors, as well as spontaneous and induced cytokine production by whole blood cells and intracellular synthesis of IFNг and IL-4 by the T-helpers from peripheral blood. It was shown that the cases complicated with subsequent compensated placental insufficiency are associated with activation of mitogen-induced cellular production of IL-1в, whereas development of subcompensated placental insufficiency is associated with increased serum levels of IL-1в and IL-1ra at early terms of gestation. An increased mitogen-induced synthesis of IFNг in blood cells represents a common risk factor for subcompensated placental insufficiency and miscarriage in the first trimester of gestation. Along with elevated mitogen-induced interferonogenesis, cellular overproduction of IL-2, as well as increased intracellular synthesis of IFNг and IL-4 by T-helpers under additional stimulation, accompanied by a growing polarization of Th1/Th2 are predictive for early reproductive losses.I. A. GazievaG. N. ChistyakovaI. I. RemizovaSPb RAACIarticlecytokine productionfirst trimester of pregnancyplacental insufficiencyearly reproductive lossesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 6, Pp 539-550 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokine production first trimester of pregnancy placental insufficiency early reproductive losses Immunologic diseases. Allergy RC581-607
spellingShingle	cytokine production first trimester of pregnancy placental insufficiency early reproductive losses Immunologic diseases. Allergy RC581-607 I. A. Gazieva G. N. Chistyakova I. I. Remizova ROLE OF CYTOKINE PRODUCTION DISORDERS IN GENESIS OF PLACENTAL INSUFFICIENCY AND EARLY REPRODUCTIVE LOSSES
description	We have analyzed clinical and laboratory data for 256 women surveyed in early pregnancy, being later classified by their pregnancy outcomes, i.e., placental insufficiency (n=106), interruption in the first trimester (n = 38) and uncomplicated cases with delivery of live, full-term infants (n = 112). We evaluated serum levels of cytokines and their soluble receptors, as well as spontaneous and induced cytokine production by whole blood cells and intracellular synthesis of IFNг and IL-4 by the T-helpers from peripheral blood. It was shown that the cases complicated with subsequent compensated placental insufficiency are associated with activation of mitogen-induced cellular production of IL-1в, whereas development of subcompensated placental insufficiency is associated with increased serum levels of IL-1в and IL-1ra at early terms of gestation. An increased mitogen-induced synthesis of IFNг in blood cells represents a common risk factor for subcompensated placental insufficiency and miscarriage in the first trimester of gestation. Along with elevated mitogen-induced interferonogenesis, cellular overproduction of IL-2, as well as increased intracellular synthesis of IFNг and IL-4 by T-helpers under additional stimulation, accompanied by a growing polarization of Th1/Th2 are predictive for early reproductive losses.
format	article
author	I. A. Gazieva G. N. Chistyakova I. I. Remizova
author_facet	I. A. Gazieva G. N. Chistyakova I. I. Remizova
author_sort	I. A. Gazieva
title	ROLE OF CYTOKINE PRODUCTION DISORDERS IN GENESIS OF PLACENTAL INSUFFICIENCY AND EARLY REPRODUCTIVE LOSSES
title_short	ROLE OF CYTOKINE PRODUCTION DISORDERS IN GENESIS OF PLACENTAL INSUFFICIENCY AND EARLY REPRODUCTIVE LOSSES
title_full	ROLE OF CYTOKINE PRODUCTION DISORDERS IN GENESIS OF PLACENTAL INSUFFICIENCY AND EARLY REPRODUCTIVE LOSSES
title_fullStr	ROLE OF CYTOKINE PRODUCTION DISORDERS IN GENESIS OF PLACENTAL INSUFFICIENCY AND EARLY REPRODUCTIVE LOSSES
title_full_unstemmed	ROLE OF CYTOKINE PRODUCTION DISORDERS IN GENESIS OF PLACENTAL INSUFFICIENCY AND EARLY REPRODUCTIVE LOSSES
title_sort	role of cytokine production disorders in genesis of placental insufficiency and early reproductive losses
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/831c093d7275425aaa9084535bd9ed5e
work_keys_str_mv	AT iagazieva roleofcytokineproductiondisordersingenesisofplacentalinsufficiencyandearlyreproductivelosses AT gnchistyakova roleofcytokineproductiondisordersingenesisofplacentalinsufficiencyandearlyreproductivelosses AT iiremizova roleofcytokineproductiondisordersingenesisofplacentalinsufficiencyandearlyreproductivelosses
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ROLE OF CYTOKINE PRODUCTION DISORDERS IN GENESIS OF PLACENTAL INSUFFICIENCY AND EARLY REPRODUCTIVE LOSSES

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