Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB

Sarah Mahboubi,1 Mohammad Nasehi,2 Alireza Imani,3,4 Mitra-Sadat Sadat-Shirazi,1–5 Mohammad-Reza Zarrindast,5–7 Nasim Vousooghi,1 Maryam Noroozian1–8 1Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran,...

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Autores principales:	Mahboubi S, Nasehi M, Imani A, Sadat-Shirazi MS, Zarrindast MR, Vousooghi N, Noroozian M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Intensive exercise Sleep Deprivation Spatial Memory Hippocampus Prefrontal Cortex BDNF TrkB Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/8320ccac541d410ea5c2c7bd2f74f605
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spelling	oai:doaj.org-article:8320ccac541d410ea5c2c7bd2f74f6052021-12-02T10:51:48ZBenefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB1179-1608https://doaj.org/article/8320ccac541d410ea5c2c7bd2f74f6052019-09-01T00:00:00Zhttps://www.dovepress.com/benefit-effect-of-rem-sleep-deprivation-on-memory-impairment-induced-b-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Sarah Mahboubi,1 Mohammad Nasehi,2 Alireza Imani,3,4 Mitra-Sadat Sadat-Shirazi,1–5 Mohammad-Reza Zarrindast,5–7 Nasim Vousooghi,1 Maryam Noroozian1–8 1Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Cognitive and Neuroscience Research Center (CNRC), Amir-Almomenin Hospital, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran; 3Department of Physiology, School of Medicine, Tehran University of Medical Science, Tehran, Iran; 4Department of Occupational Sleep Research Center, Tehran University of Medical Sciences, Tehran, Iran; 5Department of Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; 6Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 7Department of Endocrinology and Metabolism Research Institute, Tehran University of Medical Science, Tehran, Iran; 8Memory and Behavioral Neurology Division, Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, IranCorrespondence: Maryam NoroozianMemory and Behavioral Neurology Division, Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, South Kargar Avenue, P.O. Box 1333795914, Tehran, IranTel +98 21 55 419 1515Fax +98 21 5 541 9113Email mnoroozi@tums.ac.irBackground: Many factors affect our learning and memory quality, but according to different studies, having a positive or negative impact pertains to their characteristics like intensity or the amount.Purpose: The present study was conducted to investigate the effect of 24-hour REM-sleep deprivation on continuous-high intensity forced exercise-induced memory impairment and its effect on Brain-Derived Neurotrophic Factor (BDNF) and Tyrosine kinase B (TrkB) levels in the hippocampus and Prefrontal Cortex area (PFC).Material and methods: Animals were conditioned to run on treadmills for 5 weeks then, were deprived of sleep for 24 h using the modified multiple platforms. The effect of intensive exercise and/or 24-h REM-SD was studied on behavioral performance using Morris Water Maze protocol for 2 days, and BDNF/TrkB levels were assessed in hippocampus and PFC after behavioral probe test using western blotting.Results: After 5 weeks of intensive exercise and 24-h REM-SD, spatial memory impairment and reduction of BDNF and TrkB levels were found in hippocampus and PFC. 24-h REM-SD improved memory impairment and intensive exercise-induced downregulation of BDNF and TrkB protein levels.Conclusion: The results of the study suggested that sleep deprivation might act as a compensatory factor to reduce memory impairment when the animal is under severe stressful condition.Keywords: intensive exercise, sleep deprivation, spatial memory, hippocampus, prefrontal cortex, BDNF, TrkBMahboubi SNasehi MImani ASadat-Shirazi MSZarrindast MRVousooghi NNoroozian MDove Medical PressarticleIntensive exerciseSleep DeprivationSpatial MemoryHippocampusPrefrontal CortexBDNFTrkBPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 11, Pp 179-188 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Intensive exercise Sleep Deprivation Spatial Memory Hippocampus Prefrontal Cortex BDNF TrkB Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	Intensive exercise Sleep Deprivation Spatial Memory Hippocampus Prefrontal Cortex BDNF TrkB Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Mahboubi S Nasehi M Imani A Sadat-Shirazi MS Zarrindast MR Vousooghi N Noroozian M Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB
description	Sarah Mahboubi,1 Mohammad Nasehi,2 Alireza Imani,3,4 Mitra-Sadat Sadat-Shirazi,1–5 Mohammad-Reza Zarrindast,5–7 Nasim Vousooghi,1 Maryam Noroozian1–8 1Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Cognitive and Neuroscience Research Center (CNRC), Amir-Almomenin Hospital, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran; 3Department of Physiology, School of Medicine, Tehran University of Medical Science, Tehran, Iran; 4Department of Occupational Sleep Research Center, Tehran University of Medical Sciences, Tehran, Iran; 5Department of Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; 6Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 7Department of Endocrinology and Metabolism Research Institute, Tehran University of Medical Science, Tehran, Iran; 8Memory and Behavioral Neurology Division, Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, IranCorrespondence: Maryam NoroozianMemory and Behavioral Neurology Division, Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, South Kargar Avenue, P.O. Box 1333795914, Tehran, IranTel +98 21 55 419 1515Fax +98 21 5 541 9113Email mnoroozi@tums.ac.irBackground: Many factors affect our learning and memory quality, but according to different studies, having a positive or negative impact pertains to their characteristics like intensity or the amount.Purpose: The present study was conducted to investigate the effect of 24-hour REM-sleep deprivation on continuous-high intensity forced exercise-induced memory impairment and its effect on Brain-Derived Neurotrophic Factor (BDNF) and Tyrosine kinase B (TrkB) levels in the hippocampus and Prefrontal Cortex area (PFC).Material and methods: Animals were conditioned to run on treadmills for 5 weeks then, were deprived of sleep for 24 h using the modified multiple platforms. The effect of intensive exercise and/or 24-h REM-SD was studied on behavioral performance using Morris Water Maze protocol for 2 days, and BDNF/TrkB levels were assessed in hippocampus and PFC after behavioral probe test using western blotting.Results: After 5 weeks of intensive exercise and 24-h REM-SD, spatial memory impairment and reduction of BDNF and TrkB levels were found in hippocampus and PFC. 24-h REM-SD improved memory impairment and intensive exercise-induced downregulation of BDNF and TrkB protein levels.Conclusion: The results of the study suggested that sleep deprivation might act as a compensatory factor to reduce memory impairment when the animal is under severe stressful condition.Keywords: intensive exercise, sleep deprivation, spatial memory, hippocampus, prefrontal cortex, BDNF, TrkB
format	article
author	Mahboubi S Nasehi M Imani A Sadat-Shirazi MS Zarrindast MR Vousooghi N Noroozian M
author_facet	Mahboubi S Nasehi M Imani A Sadat-Shirazi MS Zarrindast MR Vousooghi N Noroozian M
author_sort	Mahboubi S
title	Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB
title_short	Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB
title_full	Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB
title_fullStr	Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB
title_full_unstemmed	Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB
title_sort	benefit effect of rem-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal bdnf and trkb
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/8320ccac541d410ea5c2c7bd2f74f605
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Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB

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