Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells

Met1-linked linear ubiquitination (M1-Ubi) is catalyzed by linear ubiquitin chain assembly complex (LUBAC). Here the authors show that Ago2 protein is M1-Ubi modified by LUBAC complex under hypoxia condition leading to less association of miRNA target mRNAs to Ago2 protein and de-repression of miRNA...

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Autores principales:	Hailong Zhang, Xian Zhao, Yanmin Guo, Ran Chen, Jianfeng He, Lian Li, Zhe Qiang, Qianqian Yang, Xiaojia Liu, Caihu Huang, Runhui Lu, Jiayu Fang, Yingting Cao, Jiayi Huang, Yanli Wang, Jian Huang, Guo-Qiang Chen, Jinke Cheng, Jianxiu Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8322c7884bf545219a1b04b3f0a7aff7
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spelling	oai:doaj.org-article:8322c7884bf545219a1b04b3f0a7aff72021-12-02T17:23:48ZHypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells10.1038/s41467-021-25739-52041-1723https://doaj.org/article/8322c7884bf545219a1b04b3f0a7aff72021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25739-5https://doaj.org/toc/2041-1723Met1-linked linear ubiquitination (M1-Ubi) is catalyzed by linear ubiquitin chain assembly complex (LUBAC). Here the authors show that Ago2 protein is M1-Ubi modified by LUBAC complex under hypoxia condition leading to less association of miRNA target mRNAs to Ago2 protein and de-repression of miRNA targets.Hailong ZhangXian ZhaoYanmin GuoRan ChenJianfeng HeLian LiZhe QiangQianqian YangXiaojia LiuCaihu HuangRunhui LuJiayu FangYingting CaoJiayi HuangYanli WangJian HuangGuo-Qiang ChenJinke ChengJianxiu YuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hailong Zhang Xian Zhao Yanmin Guo Ran Chen Jianfeng He Lian Li Zhe Qiang Qianqian Yang Xiaojia Liu Caihu Huang Runhui Lu Jiayu Fang Yingting Cao Jiayi Huang Yanli Wang Jian Huang Guo-Qiang Chen Jinke Cheng Jianxiu Yu Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells
description	Met1-linked linear ubiquitination (M1-Ubi) is catalyzed by linear ubiquitin chain assembly complex (LUBAC). Here the authors show that Ago2 protein is M1-Ubi modified by LUBAC complex under hypoxia condition leading to less association of miRNA target mRNAs to Ago2 protein and de-repression of miRNA targets.
format	article
author	Hailong Zhang Xian Zhao Yanmin Guo Ran Chen Jianfeng He Lian Li Zhe Qiang Qianqian Yang Xiaojia Liu Caihu Huang Runhui Lu Jiayu Fang Yingting Cao Jiayi Huang Yanli Wang Jian Huang Guo-Qiang Chen Jinke Cheng Jianxiu Yu
author_facet	Hailong Zhang Xian Zhao Yanmin Guo Ran Chen Jianfeng He Lian Li Zhe Qiang Qianqian Yang Xiaojia Liu Caihu Huang Runhui Lu Jiayu Fang Yingting Cao Jiayi Huang Yanli Wang Jian Huang Guo-Qiang Chen Jinke Cheng Jianxiu Yu
author_sort	Hailong Zhang
title	Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells
title_short	Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells
title_full	Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells
title_fullStr	Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells
title_full_unstemmed	Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells
title_sort	hypoxia regulates overall mrna homeostasis by inducing met1-linked linear ubiquitination of ago2 in cancer cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8322c7884bf545219a1b04b3f0a7aff7
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Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells

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