High cell-surface density of HER2 deforms cell membranes

HER2 is frequently overexpressed in breast cancer in association with increased metastatic potential. Here, the authors show that HER2 overexpression causes deformation of cell membranes in a signalling-independent manner that contributes to the disease phenotype by disrupting epithelial features.

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Autores principales:	Inhee Chung, Mike Reichelt, Lily Shao, Robert W. Akita, Hartmut Koeppen, Linda Rangell, Gabriele Schaefer, Ira Mellman, Mark X. Sliwkowski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/83242fd0be2d4fdea4e9f0c51fb02417
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spelling	oai:doaj.org-article:83242fd0be2d4fdea4e9f0c51fb024172021-12-02T14:38:54ZHigh cell-surface density of HER2 deforms cell membranes10.1038/ncomms127422041-1723https://doaj.org/article/83242fd0be2d4fdea4e9f0c51fb024172016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12742https://doaj.org/toc/2041-1723HER2 is frequently overexpressed in breast cancer in association with increased metastatic potential. Here, the authors show that HER2 overexpression causes deformation of cell membranes in a signalling-independent manner that contributes to the disease phenotype by disrupting epithelial features.Inhee ChungMike ReicheltLily ShaoRobert W. AkitaHartmut KoeppenLinda RangellGabriele SchaeferIra MellmanMark X. SliwkowskiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Inhee Chung Mike Reichelt Lily Shao Robert W. Akita Hartmut Koeppen Linda Rangell Gabriele Schaefer Ira Mellman Mark X. Sliwkowski High cell-surface density of HER2 deforms cell membranes
description	HER2 is frequently overexpressed in breast cancer in association with increased metastatic potential. Here, the authors show that HER2 overexpression causes deformation of cell membranes in a signalling-independent manner that contributes to the disease phenotype by disrupting epithelial features.
format	article
author	Inhee Chung Mike Reichelt Lily Shao Robert W. Akita Hartmut Koeppen Linda Rangell Gabriele Schaefer Ira Mellman Mark X. Sliwkowski
author_facet	Inhee Chung Mike Reichelt Lily Shao Robert W. Akita Hartmut Koeppen Linda Rangell Gabriele Schaefer Ira Mellman Mark X. Sliwkowski
author_sort	Inhee Chung
title	High cell-surface density of HER2 deforms cell membranes
title_short	High cell-surface density of HER2 deforms cell membranes
title_full	High cell-surface density of HER2 deforms cell membranes
title_fullStr	High cell-surface density of HER2 deforms cell membranes
title_full_unstemmed	High cell-surface density of HER2 deforms cell membranes
title_sort	high cell-surface density of her2 deforms cell membranes
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/83242fd0be2d4fdea4e9f0c51fb02417
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High cell-surface density of HER2 deforms cell membranes

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