Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies

In vitro blood-brain barrier (BBB) models do not fully recapitulate the in vivo barrier function. Here the authors develop an organ-on-a-chip BBB model using iPS-derived human brain endothelial cells differentiated under hypoxia, primary human pericytes and astrocytes, which maintains in vivo-like B...

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Autores principales:	Tae-Eun Park, Nur Mustafaoglu, Anna Herland, Ryan Hasselkus, Robert Mannix, Edward A. FitzGerald, Rachelle Prantil-Baun, Alexander Watters, Olivier Henry, Maximilian Benz, Henry Sanchez, Heather J. McCrea, Liliana Christova Goumnerova, Hannah W. Song, Sean P. Palecek, Eric Shusta, Donald E. Ingber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/83253cf0aed94f3c93f14d16e82efff7
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spelling	oai:doaj.org-article:83253cf0aed94f3c93f14d16e82efff72021-12-02T15:35:56ZHypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies10.1038/s41467-019-10588-02041-1723https://doaj.org/article/83253cf0aed94f3c93f14d16e82efff72019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10588-0https://doaj.org/toc/2041-1723In vitro blood-brain barrier (BBB) models do not fully recapitulate the in vivo barrier function. Here the authors develop an organ-on-a-chip BBB model using iPS-derived human brain endothelial cells differentiated under hypoxia, primary human pericytes and astrocytes, which maintains in vivo-like BBB barrier and shuttling functions for a week.Tae-Eun ParkNur MustafaogluAnna HerlandRyan HasselkusRobert MannixEdward A. FitzGeraldRachelle Prantil-BaunAlexander WattersOlivier HenryMaximilian BenzHenry SanchezHeather J. McCreaLiliana Christova GoumnerovaHannah W. SongSean P. PalecekEric ShustaDonald E. IngberNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tae-Eun Park Nur Mustafaoglu Anna Herland Ryan Hasselkus Robert Mannix Edward A. FitzGerald Rachelle Prantil-Baun Alexander Watters Olivier Henry Maximilian Benz Henry Sanchez Heather J. McCrea Liliana Christova Goumnerova Hannah W. Song Sean P. Palecek Eric Shusta Donald E. Ingber Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies
description	In vitro blood-brain barrier (BBB) models do not fully recapitulate the in vivo barrier function. Here the authors develop an organ-on-a-chip BBB model using iPS-derived human brain endothelial cells differentiated under hypoxia, primary human pericytes and astrocytes, which maintains in vivo-like BBB barrier and shuttling functions for a week.
format	article
author	Tae-Eun Park Nur Mustafaoglu Anna Herland Ryan Hasselkus Robert Mannix Edward A. FitzGerald Rachelle Prantil-Baun Alexander Watters Olivier Henry Maximilian Benz Henry Sanchez Heather J. McCrea Liliana Christova Goumnerova Hannah W. Song Sean P. Palecek Eric Shusta Donald E. Ingber
author_facet	Tae-Eun Park Nur Mustafaoglu Anna Herland Ryan Hasselkus Robert Mannix Edward A. FitzGerald Rachelle Prantil-Baun Alexander Watters Olivier Henry Maximilian Benz Henry Sanchez Heather J. McCrea Liliana Christova Goumnerova Hannah W. Song Sean P. Palecek Eric Shusta Donald E. Ingber
author_sort	Tae-Eun Park
title	Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies
title_short	Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies
title_full	Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies
title_fullStr	Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies
title_full_unstemmed	Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies
title_sort	hypoxia-enhanced blood-brain barrier chip recapitulates human barrier function and shuttling of drugs and antibodies
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/83253cf0aed94f3c93f14d16e82efff7
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Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies

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