Efficacy of silodosin on the outcome of semi-rigid ureteroscopy for the management of large distal ureteric stones: blinded randomised trial

Objective: To evaluate the efficacy of silodosin therapy, as a new α-adrenergic receptor (α-AR) blocker, on the success rate of semi-rigid ureteroscopy (URS) for the management of large distal ureteric stones. Patients and methods: This prospective study recruited 127 adult patients with single dist...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ahmed Mohey, Tarek M. Gharib, Hisham Alazaby, Mostafa Khalil, Ahmed Abou-Taleb, Yasser A. Noureldin
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/8327407aa364447081e41aa99e26176d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8327407aa364447081e41aa99e26176d
record_format	dspace
spelling	oai:doaj.org-article:8327407aa364447081e41aa99e26176d2021-12-02T10:36:47ZEfficacy of silodosin on the outcome of semi-rigid ureteroscopy for the management of large distal ureteric stones: blinded randomised trial2090-598X10.1016/j.aju.2018.07.002https://doaj.org/article/8327407aa364447081e41aa99e26176d2018-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2090598X18300676https://doaj.org/toc/2090-598XObjective: To evaluate the efficacy of silodosin therapy, as a new α-adrenergic receptor (α-AR) blocker, on the success rate of semi-rigid ureteroscopy (URS) for the management of large distal ureteric stones. Patients and methods: This prospective study recruited 127 adult patients with single distal ureteric stone of ≥1 cm. The patients were randomly allocated to two groups: the first group included 62 patients who received silodosin (8 mg) for 10 days before URS (Silodosin group), whilst the second group included 65 patients who received placebo, in the form of multivitamins, for 10 days before URS (Placebo group). All patients underwent URS and a pneumatic lithoclast was used for stone fragmentation. Results: The mean (SD) operative time was shorter in the Silodosin group compared with the Placebo group, at 41.61 (4.67) vs 46.85 (4.6) min, respectively. Furthermore, advancing the ureteroscope to access the stone failed in a statistically significant number of patients in the Placebo group compared with the Silodosin group (13 vs two, respectively). The complication rate was significantly higher in the Placebo group compared with the Silodosin group (20% vs 6.4%, P = 0.036). Additionally, the need for postoperative analgesia was significantly lower in the Silodosin group compared with the Placebo group (8.1% vs 26.2%, P = 0.009). Conclusion: Silodosin therapy prior to URS management of large distal ureteric stones seems to be associated with better advancing of the ureteroscope to access the stone, shorter procedure time, higher stone-free rate, lower incidence of complications, and lesser need for postoperative analgesia. Keywords: Silodosin, Ureteroscopy, Ureteric stones, ManagementAhmed MoheyTarek M. GharibHisham AlazabyMostafa KhalilAhmed Abou-TalebYasser A. NoureldinTaylor & Francis GrouparticleDiseases of the genitourinary system. UrologyRC870-923ENArab Journal of Urology, Vol 16, Iss 4, Pp 422-428 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Diseases of the genitourinary system. Urology RC870-923 Ahmed Mohey Tarek M. Gharib Hisham Alazaby Mostafa Khalil Ahmed Abou-Taleb Yasser A. Noureldin Efficacy of silodosin on the outcome of semi-rigid ureteroscopy for the management of large distal ureteric stones: blinded randomised trial
description	Objective: To evaluate the efficacy of silodosin therapy, as a new α-adrenergic receptor (α-AR) blocker, on the success rate of semi-rigid ureteroscopy (URS) for the management of large distal ureteric stones. Patients and methods: This prospective study recruited 127 adult patients with single distal ureteric stone of ≥1 cm. The patients were randomly allocated to two groups: the first group included 62 patients who received silodosin (8 mg) for 10 days before URS (Silodosin group), whilst the second group included 65 patients who received placebo, in the form of multivitamins, for 10 days before URS (Placebo group). All patients underwent URS and a pneumatic lithoclast was used for stone fragmentation. Results: The mean (SD) operative time was shorter in the Silodosin group compared with the Placebo group, at 41.61 (4.67) vs 46.85 (4.6) min, respectively. Furthermore, advancing the ureteroscope to access the stone failed in a statistically significant number of patients in the Placebo group compared with the Silodosin group (13 vs two, respectively). The complication rate was significantly higher in the Placebo group compared with the Silodosin group (20% vs 6.4%, P = 0.036). Additionally, the need for postoperative analgesia was significantly lower in the Silodosin group compared with the Placebo group (8.1% vs 26.2%, P = 0.009). Conclusion: Silodosin therapy prior to URS management of large distal ureteric stones seems to be associated with better advancing of the ureteroscope to access the stone, shorter procedure time, higher stone-free rate, lower incidence of complications, and lesser need for postoperative analgesia. Keywords: Silodosin, Ureteroscopy, Ureteric stones, Management
format	article
author	Ahmed Mohey Tarek M. Gharib Hisham Alazaby Mostafa Khalil Ahmed Abou-Taleb Yasser A. Noureldin
author_facet	Ahmed Mohey Tarek M. Gharib Hisham Alazaby Mostafa Khalil Ahmed Abou-Taleb Yasser A. Noureldin
author_sort	Ahmed Mohey
title	Efficacy of silodosin on the outcome of semi-rigid ureteroscopy for the management of large distal ureteric stones: blinded randomised trial
title_short	Efficacy of silodosin on the outcome of semi-rigid ureteroscopy for the management of large distal ureteric stones: blinded randomised trial
title_full	Efficacy of silodosin on the outcome of semi-rigid ureteroscopy for the management of large distal ureteric stones: blinded randomised trial
title_fullStr	Efficacy of silodosin on the outcome of semi-rigid ureteroscopy for the management of large distal ureteric stones: blinded randomised trial
title_full_unstemmed	Efficacy of silodosin on the outcome of semi-rigid ureteroscopy for the management of large distal ureteric stones: blinded randomised trial
title_sort	efficacy of silodosin on the outcome of semi-rigid ureteroscopy for the management of large distal ureteric stones: blinded randomised trial
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/8327407aa364447081e41aa99e26176d
work_keys_str_mv	AT ahmedmohey efficacyofsilodosinontheoutcomeofsemirigidureteroscopyforthemanagementoflargedistaluretericstonesblindedrandomisedtrial AT tarekmgharib efficacyofsilodosinontheoutcomeofsemirigidureteroscopyforthemanagementoflargedistaluretericstonesblindedrandomisedtrial AT hishamalazaby efficacyofsilodosinontheoutcomeofsemirigidureteroscopyforthemanagementoflargedistaluretericstonesblindedrandomisedtrial AT mostafakhalil efficacyofsilodosinontheoutcomeofsemirigidureteroscopyforthemanagementoflargedistaluretericstonesblindedrandomisedtrial AT ahmedaboutaleb efficacyofsilodosinontheoutcomeofsemirigidureteroscopyforthemanagementoflargedistaluretericstonesblindedrandomisedtrial AT yasseranoureldin efficacyofsilodosinontheoutcomeofsemirigidureteroscopyforthemanagementoflargedistaluretericstonesblindedrandomisedtrial
_version_	1718396943655239680

Efficacy of silodosin on the outcome of semi-rigid ureteroscopy for the management of large distal ureteric stones: blinded randomised trial

Ejemplares similares