Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus.

The anesthetic excitement phase occurring during induction of anesthesia with volatile anesthetics is a well-known phenomenon in clinical practice. However, the physiological mechanisms underlying anesthetic-induced excitation are still unclear. Here we provide evidence from in vitro experiments per...

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Autores principales:	Klaus Becker, Matthias Eder, Andreas Ranft, Ludwig von Meyer, Walter Zieglgänsberger, Eberhard Kochs, Hans-Ulrich Dodt
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8328dad00ca04a5685b9d1cb14a49ef9
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spelling	oai:doaj.org-article:8328dad00ca04a5685b9d1cb14a49ef92021-11-18T07:15:06ZLow dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus.1932-620310.1371/journal.pone.0039346https://doaj.org/article/8328dad00ca04a5685b9d1cb14a49ef92012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22723999/?tool=EBIhttps://doaj.org/toc/1932-6203The anesthetic excitement phase occurring during induction of anesthesia with volatile anesthetics is a well-known phenomenon in clinical practice. However, the physiological mechanisms underlying anesthetic-induced excitation are still unclear. Here we provide evidence from in vitro experiments performed on rat brain slices that the general anesthetic isoflurane at a concentration of about 0.1 mM can enhance neuronal network excitability in the hippocampus, while simultaneously reducing it in the neocortex. In contrast, isoflurane tissue concentrations above 0.3 mM expectedly caused a pronounced reduction in both brain regions. Neuronal network excitability was assessed by combining simultaneous multisite stimulation via a multielectrode array with recording intrinsic optical signals as a measure of neuronal population activity.Klaus BeckerMatthias EderAndreas RanftLudwig von MeyerWalter ZieglgänsbergerEberhard KochsHans-Ulrich DodtPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e39346 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Klaus Becker Matthias Eder Andreas Ranft Ludwig von Meyer Walter Zieglgänsberger Eberhard Kochs Hans-Ulrich Dodt Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus.
description	The anesthetic excitement phase occurring during induction of anesthesia with volatile anesthetics is a well-known phenomenon in clinical practice. However, the physiological mechanisms underlying anesthetic-induced excitation are still unclear. Here we provide evidence from in vitro experiments performed on rat brain slices that the general anesthetic isoflurane at a concentration of about 0.1 mM can enhance neuronal network excitability in the hippocampus, while simultaneously reducing it in the neocortex. In contrast, isoflurane tissue concentrations above 0.3 mM expectedly caused a pronounced reduction in both brain regions. Neuronal network excitability was assessed by combining simultaneous multisite stimulation via a multielectrode array with recording intrinsic optical signals as a measure of neuronal population activity.
format	article
author	Klaus Becker Matthias Eder Andreas Ranft Ludwig von Meyer Walter Zieglgänsberger Eberhard Kochs Hans-Ulrich Dodt
author_facet	Klaus Becker Matthias Eder Andreas Ranft Ludwig von Meyer Walter Zieglgänsberger Eberhard Kochs Hans-Ulrich Dodt
author_sort	Klaus Becker
title	Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus.
title_short	Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus.
title_full	Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus.
title_fullStr	Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus.
title_full_unstemmed	Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus.
title_sort	low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/8328dad00ca04a5685b9d1cb14a49ef9
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Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus.

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