Grey matter changes in Meige syndrome: a voxel-based morphology analysis

Abstract To investigate the changes and clinical significance of brain structural abnormalities in patients with Meige syndrome and related depressive symptoms. We retrospectively analysed clinical data, imaging examinations, and Hamilton Depression Rating scale scores in 46 patients with Meige synd...

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Autores principales:	Jiayu Liu, Lei Li, Lei Chen, Ruen Liu, Yongan Jiang, Jixia Fang, Dongliang Wang, Zhi Liu, Jia Ouyang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/832c412a617642eb98794413b910c7b1
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spelling	oai:doaj.org-article:832c412a617642eb98794413b910c7b12021-12-02T19:09:30ZGrey matter changes in Meige syndrome: a voxel-based morphology analysis10.1038/s41598-020-71479-92045-2322https://doaj.org/article/832c412a617642eb98794413b910c7b12020-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-71479-9https://doaj.org/toc/2045-2322Abstract To investigate the changes and clinical significance of brain structural abnormalities in patients with Meige syndrome and related depressive symptoms. We retrospectively analysed clinical data, imaging examinations, and Hamilton Depression Rating scale scores in 46 patients with Meige syndrome from January 2017 to January 2019. We compared the Meige syndrome group with the healthy control group, and the definite depression group with the non-definite depression group. Voxel-based morphometry (VBM) was used to compare grey matter (GM) volumes. We conducted two-sample t-tests corrected for subject age and gender. We tested at a level of significance of p < 0.001 with a false discovery rate (FDR) correction. VBM demonstrated decreased GM volume (p < 0.001 and cluster size > 50 voxels) in the left hemisphere in the middle frontal orbital gyrus, temporal pole (superior temporal gyrus) and insula and in the right hemisphere in the temporal pole (middle temporal gyrus), precuneus, inferior parietal, inferior temporal and olfactory cortices in the Meige syndrome group. Comparing VBM-MRI measures in Meige syndrome patients with and without depression, decreased GM volume was found in the left hemisphere in the cuneus and hippocampus and in the right hemisphere in the angular gyrus, middle frontal gyrus and middle occipital gyrus in the definite depression group. Unlike other dystonia studies that have suggested an involvement of the basal ganglia and motor cortex in the pathophysiology of the disorder , we believe that the precuneus is involved in the development of Meige syndrome. Additionally, our findings suggest that the hippocampus plays a role in the pathogenesis of depression in patients with Meige syndrome.Jiayu LiuLei LiLei ChenRuen LiuYongan JiangJixia FangDongliang WangZhi LiuJia OuyangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiayu Liu Lei Li Lei Chen Ruen Liu Yongan Jiang Jixia Fang Dongliang Wang Zhi Liu Jia Ouyang Grey matter changes in Meige syndrome: a voxel-based morphology analysis
description	Abstract To investigate the changes and clinical significance of brain structural abnormalities in patients with Meige syndrome and related depressive symptoms. We retrospectively analysed clinical data, imaging examinations, and Hamilton Depression Rating scale scores in 46 patients with Meige syndrome from January 2017 to January 2019. We compared the Meige syndrome group with the healthy control group, and the definite depression group with the non-definite depression group. Voxel-based morphometry (VBM) was used to compare grey matter (GM) volumes. We conducted two-sample t-tests corrected for subject age and gender. We tested at a level of significance of p < 0.001 with a false discovery rate (FDR) correction. VBM demonstrated decreased GM volume (p < 0.001 and cluster size > 50 voxels) in the left hemisphere in the middle frontal orbital gyrus, temporal pole (superior temporal gyrus) and insula and in the right hemisphere in the temporal pole (middle temporal gyrus), precuneus, inferior parietal, inferior temporal and olfactory cortices in the Meige syndrome group. Comparing VBM-MRI measures in Meige syndrome patients with and without depression, decreased GM volume was found in the left hemisphere in the cuneus and hippocampus and in the right hemisphere in the angular gyrus, middle frontal gyrus and middle occipital gyrus in the definite depression group. Unlike other dystonia studies that have suggested an involvement of the basal ganglia and motor cortex in the pathophysiology of the disorder , we believe that the precuneus is involved in the development of Meige syndrome. Additionally, our findings suggest that the hippocampus plays a role in the pathogenesis of depression in patients with Meige syndrome.
format	article
author	Jiayu Liu Lei Li Lei Chen Ruen Liu Yongan Jiang Jixia Fang Dongliang Wang Zhi Liu Jia Ouyang
author_facet	Jiayu Liu Lei Li Lei Chen Ruen Liu Yongan Jiang Jixia Fang Dongliang Wang Zhi Liu Jia Ouyang
author_sort	Jiayu Liu
title	Grey matter changes in Meige syndrome: a voxel-based morphology analysis
title_short	Grey matter changes in Meige syndrome: a voxel-based morphology analysis
title_full	Grey matter changes in Meige syndrome: a voxel-based morphology analysis
title_fullStr	Grey matter changes in Meige syndrome: a voxel-based morphology analysis
title_full_unstemmed	Grey matter changes in Meige syndrome: a voxel-based morphology analysis
title_sort	grey matter changes in meige syndrome: a voxel-based morphology analysis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/832c412a617642eb98794413b910c7b1
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Grey matter changes in Meige syndrome: a voxel-based morphology analysis

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