Analysis of factors affecting the therapeutic effect of propranolol for infantile haemangioma of the head and neck

Abstract Infantile haemangiomas (IHs) are the most common congenital vascular tumours of infancy. Propranolol has been demonstrated to be effective for IHs; however, the factors affecting its therapeutic effect remain unknown. We enrolled 169 infants with IHs of the head and neck region treated with...

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Autores principales:	Jian-Yong Dong, Jie-Xin Ning, Kai Li, Chao Liu, Xu-Xia Wang, Rong-Hui Li, Lin-Lin Yue, Ying-Ying Huang, Shao-Hua Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/832d0a979e5d4bc5be9006d19f50ee6a
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spelling	oai:doaj.org-article:832d0a979e5d4bc5be9006d19f50ee6a2021-12-02T15:06:25ZAnalysis of factors affecting the therapeutic effect of propranolol for infantile haemangioma of the head and neck10.1038/s41598-017-00495-z2045-2322https://doaj.org/article/832d0a979e5d4bc5be9006d19f50ee6a2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00495-zhttps://doaj.org/toc/2045-2322Abstract Infantile haemangiomas (IHs) are the most common congenital vascular tumours of infancy. Propranolol has been demonstrated to be effective for IHs; however, the factors affecting its therapeutic effect remain unknown. We enrolled 169 infants with IHs of the head and neck region treated with oral propranolol at a dose of 2.0 mg/kg/day. We evaluated the therapeutic responses 6 months after treatment and the end of treatment, which were categorized into four grades. The type and location of the lesions and the infant age at treatment initiation were analysed. The clinical response rate (III + IV) was 91.72% at 6 months after treatment and 97.63% at the end of treatment. The average treatment duration was 9.99 (2–24) months. The group aged 4–6 months exhibited a greater therapeutic response rate (98.48%). The treatment duration was shorter (9.52 months) for mixed-type IHs. Better therapeutic responses were observed for IHs located around the parotid, periorbital, cheek, and neck regions and for multiple IH lesions. Our study indicated that propranolol is effective for IHs affecting the head and neck. The age at treatment initiation and the location of the lesions had a significant effect on the therapeutic response, whereas the lesion type might affect the treatment duration.Jian-Yong DongJie-Xin NingKai LiChao LiuXu-Xia WangRong-Hui LiLin-Lin YueYing-Ying HuangShao-Hua LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jian-Yong Dong Jie-Xin Ning Kai Li Chao Liu Xu-Xia Wang Rong-Hui Li Lin-Lin Yue Ying-Ying Huang Shao-Hua Liu Analysis of factors affecting the therapeutic effect of propranolol for infantile haemangioma of the head and neck
description	Abstract Infantile haemangiomas (IHs) are the most common congenital vascular tumours of infancy. Propranolol has been demonstrated to be effective for IHs; however, the factors affecting its therapeutic effect remain unknown. We enrolled 169 infants with IHs of the head and neck region treated with oral propranolol at a dose of 2.0 mg/kg/day. We evaluated the therapeutic responses 6 months after treatment and the end of treatment, which were categorized into four grades. The type and location of the lesions and the infant age at treatment initiation were analysed. The clinical response rate (III + IV) was 91.72% at 6 months after treatment and 97.63% at the end of treatment. The average treatment duration was 9.99 (2–24) months. The group aged 4–6 months exhibited a greater therapeutic response rate (98.48%). The treatment duration was shorter (9.52 months) for mixed-type IHs. Better therapeutic responses were observed for IHs located around the parotid, periorbital, cheek, and neck regions and for multiple IH lesions. Our study indicated that propranolol is effective for IHs affecting the head and neck. The age at treatment initiation and the location of the lesions had a significant effect on the therapeutic response, whereas the lesion type might affect the treatment duration.
format	article
author	Jian-Yong Dong Jie-Xin Ning Kai Li Chao Liu Xu-Xia Wang Rong-Hui Li Lin-Lin Yue Ying-Ying Huang Shao-Hua Liu
author_facet	Jian-Yong Dong Jie-Xin Ning Kai Li Chao Liu Xu-Xia Wang Rong-Hui Li Lin-Lin Yue Ying-Ying Huang Shao-Hua Liu
author_sort	Jian-Yong Dong
title	Analysis of factors affecting the therapeutic effect of propranolol for infantile haemangioma of the head and neck
title_short	Analysis of factors affecting the therapeutic effect of propranolol for infantile haemangioma of the head and neck
title_full	Analysis of factors affecting the therapeutic effect of propranolol for infantile haemangioma of the head and neck
title_fullStr	Analysis of factors affecting the therapeutic effect of propranolol for infantile haemangioma of the head and neck
title_full_unstemmed	Analysis of factors affecting the therapeutic effect of propranolol for infantile haemangioma of the head and neck
title_sort	analysis of factors affecting the therapeutic effect of propranolol for infantile haemangioma of the head and neck
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/832d0a979e5d4bc5be9006d19f50ee6a
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Analysis of factors affecting the therapeutic effect of propranolol for infantile haemangioma of the head and neck

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