Estimating dispensable content in the human interactome

The fraction of protein-protein interactions (PPIs) that can be disrupted without fitness effect is unknown. Here, the authors model how disease-causing mutations and common mutations carried by healthy people perturb the interactome, and estimate that <20% of human PPIs are completely dispensabl...

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Autores principales:	Mohamed Ghadie, Yu Xia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/832f9050602048b3a2df38bdf6eafc8e
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spelling	oai:doaj.org-article:832f9050602048b3a2df38bdf6eafc8e2021-12-02T17:02:15ZEstimating dispensable content in the human interactome10.1038/s41467-019-11180-22041-1723https://doaj.org/article/832f9050602048b3a2df38bdf6eafc8e2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11180-2https://doaj.org/toc/2041-1723The fraction of protein-protein interactions (PPIs) that can be disrupted without fitness effect is unknown. Here, the authors model how disease-causing mutations and common mutations carried by healthy people perturb the interactome, and estimate that <20% of human PPIs are completely dispensable.Mohamed GhadieYu XiaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mohamed Ghadie Yu Xia Estimating dispensable content in the human interactome
description	The fraction of protein-protein interactions (PPIs) that can be disrupted without fitness effect is unknown. Here, the authors model how disease-causing mutations and common mutations carried by healthy people perturb the interactome, and estimate that <20% of human PPIs are completely dispensable.
format	article
author	Mohamed Ghadie Yu Xia
author_facet	Mohamed Ghadie Yu Xia
author_sort	Mohamed Ghadie
title	Estimating dispensable content in the human interactome
title_short	Estimating dispensable content in the human interactome
title_full	Estimating dispensable content in the human interactome
title_fullStr	Estimating dispensable content in the human interactome
title_full_unstemmed	Estimating dispensable content in the human interactome
title_sort	estimating dispensable content in the human interactome
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/832f9050602048b3a2df38bdf6eafc8e
work_keys_str_mv	AT mohamedghadie estimatingdispensablecontentinthehumaninteractome AT yuxia estimatingdispensablecontentinthehumaninteractome
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Estimating dispensable content in the human interactome

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