EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity

EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity

It is unclear why neuronal activity induced methylation changes are limited to specific loci in the genome. Here, authors show that the DNA demethylation enzyme, TET1, gains its specificity via the interaction with EGR1, a sequence specific DNA binding protein.

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Detalles Bibliográficos
Autores principales: Zhixiong Sun, Xiguang Xu, Jianlin He, Alexander Murray, Ming-an Sun, Xiaoran Wei, Xia Wang, Emmarose McCoig, Evan Xie, Xi Jiang, Liwu Li, Jinsong Zhu, Jianjun Chen, Alexei Morozov, Alicia M. Pickrell, Michelle H. Theus, Hehuang Xie
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/833197c688f54d60ab4edcc1365addf1
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Descripción
Sumario:It is unclear why neuronal activity induced methylation changes are limited to specific loci in the genome. Here, authors show that the DNA demethylation enzyme, TET1, gains its specificity via the interaction with EGR1, a sequence specific DNA binding protein.

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