EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity

It is unclear why neuronal activity induced methylation changes are limited to specific loci in the genome. Here, authors show that the DNA demethylation enzyme, TET1, gains its specificity via the interaction with EGR1, a sequence specific DNA binding protein.

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Autores principales:	Zhixiong Sun, Xiguang Xu, Jianlin He, Alexander Murray, Ming-an Sun, Xiaoran Wei, Xia Wang, Emmarose McCoig, Evan Xie, Xi Jiang, Liwu Li, Jinsong Zhu, Jianjun Chen, Alexei Morozov, Alicia M. Pickrell, Michelle H. Theus, Hehuang Xie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/833197c688f54d60ab4edcc1365addf1
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spelling	oai:doaj.org-article:833197c688f54d60ab4edcc1365addf12021-12-02T15:35:54ZEGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity10.1038/s41467-019-11905-32041-1723https://doaj.org/article/833197c688f54d60ab4edcc1365addf12019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11905-3https://doaj.org/toc/2041-1723It is unclear why neuronal activity induced methylation changes are limited to specific loci in the genome. Here, authors show that the DNA demethylation enzyme, TET1, gains its specificity via the interaction with EGR1, a sequence specific DNA binding protein.Zhixiong SunXiguang XuJianlin HeAlexander MurrayMing-an SunXiaoran WeiXia WangEmmarose McCoigEvan XieXi JiangLiwu LiJinsong ZhuJianjun ChenAlexei MorozovAlicia M. PickrellMichelle H. TheusHehuang XieNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhixiong Sun Xiguang Xu Jianlin He Alexander Murray Ming-an Sun Xiaoran Wei Xia Wang Emmarose McCoig Evan Xie Xi Jiang Liwu Li Jinsong Zhu Jianjun Chen Alexei Morozov Alicia M. Pickrell Michelle H. Theus Hehuang Xie EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity
description	It is unclear why neuronal activity induced methylation changes are limited to specific loci in the genome. Here, authors show that the DNA demethylation enzyme, TET1, gains its specificity via the interaction with EGR1, a sequence specific DNA binding protein.
format	article
author	Zhixiong Sun Xiguang Xu Jianlin He Alexander Murray Ming-an Sun Xiaoran Wei Xia Wang Emmarose McCoig Evan Xie Xi Jiang Liwu Li Jinsong Zhu Jianjun Chen Alexei Morozov Alicia M. Pickrell Michelle H. Theus Hehuang Xie
author_facet	Zhixiong Sun Xiguang Xu Jianlin He Alexander Murray Ming-an Sun Xiaoran Wei Xia Wang Emmarose McCoig Evan Xie Xi Jiang Liwu Li Jinsong Zhu Jianjun Chen Alexei Morozov Alicia M. Pickrell Michelle H. Theus Hehuang Xie
author_sort	Zhixiong Sun
title	EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity
title_short	EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity
title_full	EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity
title_fullStr	EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity
title_full_unstemmed	EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity
title_sort	egr1 recruits tet1 to shape the brain methylome during development and upon neuronal activity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/833197c688f54d60ab4edcc1365addf1
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EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity

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