Catheter-related bloodstream infection associated with multiple insertions of the peripherally inserted central catheter in patients with hematological disorders

Abstract Patients with hematological disorders are treated with multiple cycles of chemotherapy. As a result, they often require multiple insertions of the peripherally inserted central catheter (PICC) for prolonged periods of time. Although PICCs have been widely used worldwide in various patients,...

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Autores principales:	Yoshinori Hashimoto, Rina Hosoda, Hiromi Omura, Takayuki Tanaka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/833221ff9e9d4e37951ef3f2f558faa3
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spelling	oai:doaj.org-article:833221ff9e9d4e37951ef3f2f558faa32021-12-02T17:48:00ZCatheter-related bloodstream infection associated with multiple insertions of the peripherally inserted central catheter in patients with hematological disorders10.1038/s41598-021-91749-42045-2322https://doaj.org/article/833221ff9e9d4e37951ef3f2f558faa32021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91749-4https://doaj.org/toc/2045-2322Abstract Patients with hematological disorders are treated with multiple cycles of chemotherapy. As a result, they often require multiple insertions of the peripherally inserted central catheter (PICC) for prolonged periods of time. Although PICCs have been widely used worldwide in various patients, the safety and feasibility of the multiple insertions of the PICC in this population have not been fully verified. We performed a retrospective analysis to clarify the relationship between complications and multiple PICC insertions in patients with hematological disorders who were treated with either chemotherapy or immunotherapy. A total of 651 PICCs were inserted in 261 patients with a median age of 66 years. Acute myeloid leukemia (AML) and non-Hodgkin's lymphoma were the most common diseases in our patient cohort. The total catheter days (CDs) was 29,485 days, with a median catheter duration of 30 days. The rate of catheter-related bloodstream infection (CRBSI) in our patient cohort at high rate of re-insertion was 2.0/1000 CDs. Although multiple PICC insertions were not a risk factor of CRBSI, our findings suggest that a prolonged catheter dwell time may be associated with CRBSI. AML was an important risk factor of CRBSI. While the PICC dwell time depends on the treatment cycle, our findings indicate that it should be limited to approximately 30 days and catheters may be removed and re-inserted as needed.Yoshinori HashimotoRina HosodaHiromi OmuraTakayuki TanakaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoshinori Hashimoto Rina Hosoda Hiromi Omura Takayuki Tanaka Catheter-related bloodstream infection associated with multiple insertions of the peripherally inserted central catheter in patients with hematological disorders
description	Abstract Patients with hematological disorders are treated with multiple cycles of chemotherapy. As a result, they often require multiple insertions of the peripherally inserted central catheter (PICC) for prolonged periods of time. Although PICCs have been widely used worldwide in various patients, the safety and feasibility of the multiple insertions of the PICC in this population have not been fully verified. We performed a retrospective analysis to clarify the relationship between complications and multiple PICC insertions in patients with hematological disorders who were treated with either chemotherapy or immunotherapy. A total of 651 PICCs were inserted in 261 patients with a median age of 66 years. Acute myeloid leukemia (AML) and non-Hodgkin's lymphoma were the most common diseases in our patient cohort. The total catheter days (CDs) was 29,485 days, with a median catheter duration of 30 days. The rate of catheter-related bloodstream infection (CRBSI) in our patient cohort at high rate of re-insertion was 2.0/1000 CDs. Although multiple PICC insertions were not a risk factor of CRBSI, our findings suggest that a prolonged catheter dwell time may be associated with CRBSI. AML was an important risk factor of CRBSI. While the PICC dwell time depends on the treatment cycle, our findings indicate that it should be limited to approximately 30 days and catheters may be removed and re-inserted as needed.
format	article
author	Yoshinori Hashimoto Rina Hosoda Hiromi Omura Takayuki Tanaka
author_facet	Yoshinori Hashimoto Rina Hosoda Hiromi Omura Takayuki Tanaka
author_sort	Yoshinori Hashimoto
title	Catheter-related bloodstream infection associated with multiple insertions of the peripherally inserted central catheter in patients with hematological disorders
title_short	Catheter-related bloodstream infection associated with multiple insertions of the peripherally inserted central catheter in patients with hematological disorders
title_full	Catheter-related bloodstream infection associated with multiple insertions of the peripherally inserted central catheter in patients with hematological disorders
title_fullStr	Catheter-related bloodstream infection associated with multiple insertions of the peripherally inserted central catheter in patients with hematological disorders
title_full_unstemmed	Catheter-related bloodstream infection associated with multiple insertions of the peripherally inserted central catheter in patients with hematological disorders
title_sort	catheter-related bloodstream infection associated with multiple insertions of the peripherally inserted central catheter in patients with hematological disorders
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/833221ff9e9d4e37951ef3f2f558faa3
work_keys_str_mv	AT yoshinorihashimoto catheterrelatedbloodstreaminfectionassociatedwithmultipleinsertionsoftheperipherallyinsertedcentralcatheterinpatientswithhematologicaldisorders AT rinahosoda catheterrelatedbloodstreaminfectionassociatedwithmultipleinsertionsoftheperipherallyinsertedcentralcatheterinpatientswithhematologicaldisorders AT hiromiomura catheterrelatedbloodstreaminfectionassociatedwithmultipleinsertionsoftheperipherallyinsertedcentralcatheterinpatientswithhematologicaldisorders AT takayukitanaka catheterrelatedbloodstreaminfectionassociatedwithmultipleinsertionsoftheperipherallyinsertedcentralcatheterinpatientswithhematologicaldisorders
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Catheter-related bloodstream infection associated with multiple insertions of the peripherally inserted central catheter in patients with hematological disorders

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