Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma

Abstract Background Both activated tumor-infiltrating lymphocytes (TILs) and immune-suppressive cells, such as regulatory T cells (Tregs), in the tumor microenvironment (TME) play an important role in the prognosis of patients with pancreatic ductal adenocarcinoma (PDAC). Methods The densities of TI...

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Autores principales:	Sachie Kiryu, Zensho Ito, Machi Suka, Tsuuse Bito, Shin Kan, Kan Uchiyama, Masayuki Saruta, Taigo Hata, Yuki Takano, Shuichi Fujioka, Takeyuki Misawa, Takashi Yamauchi, Hiroyuki Yanagisawa, Nobuhiro Sato, Toshifumi Ohkusa, Haruo Sugiyama, Shigeo Koido
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Foxp3 Immune-related cells Pancreatic cancer Prognosis PD-1 TIL Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8336055c81c24d62a8789f312e8859d7
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spelling	oai:doaj.org-article:8336055c81c24d62a8789f312e8859d72021-11-14T12:29:49ZPrognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma10.1186/s12885-021-08911-41471-2407https://doaj.org/article/8336055c81c24d62a8789f312e8859d72021-11-01T00:00:00Zhttps://doi.org/10.1186/s12885-021-08911-4https://doaj.org/toc/1471-2407Abstract Background Both activated tumor-infiltrating lymphocytes (TILs) and immune-suppressive cells, such as regulatory T cells (Tregs), in the tumor microenvironment (TME) play an important role in the prognosis of patients with pancreatic ductal adenocarcinoma (PDAC). Methods The densities of TILs, programmed death receptor 1 (PD-1) + T cells, and forkhead box P3 (Foxp3) + T cells were analyzed by immunohistochemical staining. The associations of the immunological status of the PDAC microenvironment with overall survival (OS) time and disease-free survival (DFS) time were evaluated. Results PDAC patients with a high density of TILs in the TME or PD-1-positive T cells in tertiary lymphoid aggregates (TLAs) demonstrated a significantly better prognosis than those with a low density of TILs or PD-1-negativity, respectively. Moreover, PDAC patients with high levels of Foxp3-expressing T cells showed a worse prognosis than those with low levels of Foxp3-expressing T cells. Importantly, even with a high density of the TILs in TME or PD-1-positive T cells in TLAs, PDAC patients with high levels of Foxp3-expressing T cells showed a worse prognosis than patients with low levels of Foxp3-expressing T cells. A PDAC TME with a high density of TILs/high PD-1 positivity/low Foxp3 expression was an independent predictive marker associated with superior prognosis. Conclusion Combined assessment of TILs, PD-1+ cells, and Foxp3+ T cells in the TME may predict the prognosis of PDAC patients following surgical resection.Sachie KiryuZensho ItoMachi SukaTsuuse BitoShin KanKan UchiyamaMasayuki SarutaTaigo HataYuki TakanoShuichi FujiokaTakeyuki MisawaTakashi YamauchiHiroyuki YanagisawaNobuhiro SatoToshifumi OhkusaHaruo SugiyamaShigeo KoidoBMCarticleFoxp3Immune-related cellsPancreatic cancerPrognosisPD-1TILNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Foxp3 Immune-related cells Pancreatic cancer Prognosis PD-1 TIL Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Foxp3 Immune-related cells Pancreatic cancer Prognosis PD-1 TIL Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Sachie Kiryu Zensho Ito Machi Suka Tsuuse Bito Shin Kan Kan Uchiyama Masayuki Saruta Taigo Hata Yuki Takano Shuichi Fujioka Takeyuki Misawa Takashi Yamauchi Hiroyuki Yanagisawa Nobuhiro Sato Toshifumi Ohkusa Haruo Sugiyama Shigeo Koido Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma
description	Abstract Background Both activated tumor-infiltrating lymphocytes (TILs) and immune-suppressive cells, such as regulatory T cells (Tregs), in the tumor microenvironment (TME) play an important role in the prognosis of patients with pancreatic ductal adenocarcinoma (PDAC). Methods The densities of TILs, programmed death receptor 1 (PD-1) + T cells, and forkhead box P3 (Foxp3) + T cells were analyzed by immunohistochemical staining. The associations of the immunological status of the PDAC microenvironment with overall survival (OS) time and disease-free survival (DFS) time were evaluated. Results PDAC patients with a high density of TILs in the TME or PD-1-positive T cells in tertiary lymphoid aggregates (TLAs) demonstrated a significantly better prognosis than those with a low density of TILs or PD-1-negativity, respectively. Moreover, PDAC patients with high levels of Foxp3-expressing T cells showed a worse prognosis than those with low levels of Foxp3-expressing T cells. Importantly, even with a high density of the TILs in TME or PD-1-positive T cells in TLAs, PDAC patients with high levels of Foxp3-expressing T cells showed a worse prognosis than patients with low levels of Foxp3-expressing T cells. A PDAC TME with a high density of TILs/high PD-1 positivity/low Foxp3 expression was an independent predictive marker associated with superior prognosis. Conclusion Combined assessment of TILs, PD-1+ cells, and Foxp3+ T cells in the TME may predict the prognosis of PDAC patients following surgical resection.
format	article
author	Sachie Kiryu Zensho Ito Machi Suka Tsuuse Bito Shin Kan Kan Uchiyama Masayuki Saruta Taigo Hata Yuki Takano Shuichi Fujioka Takeyuki Misawa Takashi Yamauchi Hiroyuki Yanagisawa Nobuhiro Sato Toshifumi Ohkusa Haruo Sugiyama Shigeo Koido
author_facet	Sachie Kiryu Zensho Ito Machi Suka Tsuuse Bito Shin Kan Kan Uchiyama Masayuki Saruta Taigo Hata Yuki Takano Shuichi Fujioka Takeyuki Misawa Takashi Yamauchi Hiroyuki Yanagisawa Nobuhiro Sato Toshifumi Ohkusa Haruo Sugiyama Shigeo Koido
author_sort	Sachie Kiryu
title	Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma
title_short	Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma
title_full	Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma
title_fullStr	Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma
title_full_unstemmed	Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma
title_sort	prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma
publisher	BMC
publishDate	2021
url	https://doaj.org/article/8336055c81c24d62a8789f312e8859d7
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Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma

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