A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice

Oxidized phospholipids have diverse biological activities, many of which can be pathological, yet how they are inactivated in vivo is not fully understood. Here, we present evidence that a highly conserved host lipase, acyloxyacyl hydrolase (AOAH), can play a significant role in reducing the pro-inf...

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Autores principales:	Benkun Zou, Michael Goodwin, Danial Saleem, Wei Jiang, Jianguo Tang, Yiwei Chu, Robert S Munford, Mingfang Lu
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	acyloxyacyl hydrolase oxidized phospholipid macrophage inflammasome acute lung injury Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8336c58698cd4c66a2824f8ee4b95e13
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spelling	oai:doaj.org-article:8336c58698cd4c66a2824f8ee4b95e132021-11-24T12:26:04ZA highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice10.7554/eLife.709382050-084Xe70938https://doaj.org/article/8336c58698cd4c66a2824f8ee4b95e132021-11-01T00:00:00Zhttps://elifesciences.org/articles/70938https://doaj.org/toc/2050-084XOxidized phospholipids have diverse biological activities, many of which can be pathological, yet how they are inactivated in vivo is not fully understood. Here, we present evidence that a highly conserved host lipase, acyloxyacyl hydrolase (AOAH), can play a significant role in reducing the pro-inflammatory activities of two prominent products of phospholipid oxidation, 1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine and 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine. AOAH removed the sn-2 and sn-1 acyl chains from both lipids and reduced their ability to induce macrophage inflammasome activation and cell death in vitro and acute lung injury in mice. In addition to transforming Gram-negative bacterial lipopolysaccharide from stimulus to inhibitor, its most studied activity, AOAH can inactivate these important danger-associated molecular pattern molecules and reduce tissue inflammation and injury.Benkun ZouMichael GoodwinDanial SaleemWei JiangJianguo TangYiwei ChuRobert S MunfordMingfang LueLife Sciences Publications Ltdarticleacyloxyacyl hydrolaseoxidized phospholipidmacrophageinflammasomeacute lung injuryMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acyloxyacyl hydrolase oxidized phospholipid macrophage inflammasome acute lung injury Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	acyloxyacyl hydrolase oxidized phospholipid macrophage inflammasome acute lung injury Medicine R Science Q Biology (General) QH301-705.5 Benkun Zou Michael Goodwin Danial Saleem Wei Jiang Jianguo Tang Yiwei Chu Robert S Munford Mingfang Lu A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice
description	Oxidized phospholipids have diverse biological activities, many of which can be pathological, yet how they are inactivated in vivo is not fully understood. Here, we present evidence that a highly conserved host lipase, acyloxyacyl hydrolase (AOAH), can play a significant role in reducing the pro-inflammatory activities of two prominent products of phospholipid oxidation, 1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine and 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine. AOAH removed the sn-2 and sn-1 acyl chains from both lipids and reduced their ability to induce macrophage inflammasome activation and cell death in vitro and acute lung injury in mice. In addition to transforming Gram-negative bacterial lipopolysaccharide from stimulus to inhibitor, its most studied activity, AOAH can inactivate these important danger-associated molecular pattern molecules and reduce tissue inflammation and injury.
format	article
author	Benkun Zou Michael Goodwin Danial Saleem Wei Jiang Jianguo Tang Yiwei Chu Robert S Munford Mingfang Lu
author_facet	Benkun Zou Michael Goodwin Danial Saleem Wei Jiang Jianguo Tang Yiwei Chu Robert S Munford Mingfang Lu
author_sort	Benkun Zou
title	A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice
title_short	A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice
title_full	A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice
title_fullStr	A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice
title_full_unstemmed	A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice
title_sort	highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/8336c58698cd4c66a2824f8ee4b95e13
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A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice

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