IKZF1 deletions associate with CRLF2 overexpression leading to a poor prognosis in B-cell precursor acute lymphoblastic leukaemia

IKZF1 deletions associate with CRLF2 overexpression leading to a poor prognosis in B-cell precursor acute lymphoblastic leukaemia

Cytokine Receptor-Like Factor 2 (CRLF2) overexpression occurs in 5-15% of B-cell precursor acute lymphoblastic leukaemia (B-ALL). In ∼50% of these cases, the mechanisms underlying this dysregulation are unknown. IKAROS Family Zinc Finger 1 (IKZF1) is a possible candidate to play a role in this dysre...

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Autores principales: Ana Luiza Tardem Maciel, Thayana da Conceição Barbosa, Caroline Barbieri Blunck, Karolyne Wolch, Amanda de Albuquerque Lopes Machado, Elaine Sobral da Costa, Lavínia Lustosa Bergier, Márcia Trindade Schramm, Maura Rosane Valério Ikoma-Coltutato, Mecneide Mendes Lins, Thais Ferraz Aguiar, Marcela Braga Mansur, Mariana Emerenciano
Formato: article
Lenguaje:EN
Publicado: Elsevier 2022
Materias:
CRLF2, IKZF1, Gene expression
Gene deletions
Outcome
B-ALL
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/8339161c8984493e87427f6188e1cfae
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