miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint

Resistance to chemotherapy occurs in many ovarian cancer cases. Here, the authors show that mir-424(322) expression restores the sensitivity of ovarian cancer cells to chemotherapy by blocking the PD-L1 immune checkpoint, and find that combining immunotherapy and chemotherapy has a synergistic effec...

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Autores principales:	Shaohua Xu, Zhen Tao, Bo Hai, Huagen Liang, Ying Shi, Tao Wang, Wen Song, Yong Chen, Jun OuYang, Jinhong Chen, Fanfei Kong, Yishan Dong, Shi-Wen Jiang, Weiyong Li, Ping Wang, Zhiyong Yuan, Xiaoping Wan, Chenguang Wang, Wencheng Li, Xiaoping Zhang, Ke Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/83393a4ad9904862b71afa90aa143e94
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spelling	oai:doaj.org-article:83393a4ad9904862b71afa90aa143e942021-12-02T14:40:15ZmiR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint10.1038/ncomms114062041-1723https://doaj.org/article/83393a4ad9904862b71afa90aa143e942016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11406https://doaj.org/toc/2041-1723Resistance to chemotherapy occurs in many ovarian cancer cases. Here, the authors show that mir-424(322) expression restores the sensitivity of ovarian cancer cells to chemotherapy by blocking the PD-L1 immune checkpoint, and find that combining immunotherapy and chemotherapy has a synergistic effect.Shaohua XuZhen TaoBo HaiHuagen LiangYing ShiTao WangWen SongYong ChenJun OuYangJinhong ChenFanfei KongYishan DongShi-Wen JiangWeiyong LiPing WangZhiyong YuanXiaoping WanChenguang WangWencheng LiXiaoping ZhangKe ChenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shaohua Xu Zhen Tao Bo Hai Huagen Liang Ying Shi Tao Wang Wen Song Yong Chen Jun OuYang Jinhong Chen Fanfei Kong Yishan Dong Shi-Wen Jiang Weiyong Li Ping Wang Zhiyong Yuan Xiaoping Wan Chenguang Wang Wencheng Li Xiaoping Zhang Ke Chen miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint
description	Resistance to chemotherapy occurs in many ovarian cancer cases. Here, the authors show that mir-424(322) expression restores the sensitivity of ovarian cancer cells to chemotherapy by blocking the PD-L1 immune checkpoint, and find that combining immunotherapy and chemotherapy has a synergistic effect.
format	article
author	Shaohua Xu Zhen Tao Bo Hai Huagen Liang Ying Shi Tao Wang Wen Song Yong Chen Jun OuYang Jinhong Chen Fanfei Kong Yishan Dong Shi-Wen Jiang Weiyong Li Ping Wang Zhiyong Yuan Xiaoping Wan Chenguang Wang Wencheng Li Xiaoping Zhang Ke Chen
author_facet	Shaohua Xu Zhen Tao Bo Hai Huagen Liang Ying Shi Tao Wang Wen Song Yong Chen Jun OuYang Jinhong Chen Fanfei Kong Yishan Dong Shi-Wen Jiang Weiyong Li Ping Wang Zhiyong Yuan Xiaoping Wan Chenguang Wang Wencheng Li Xiaoping Zhang Ke Chen
author_sort	Shaohua Xu
title	miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint
title_short	miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint
title_full	miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint
title_fullStr	miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint
title_full_unstemmed	miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint
title_sort	mir-424(322) reverses chemoresistance via t-cell immune response activation by blocking the pd-l1 immune checkpoint
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/83393a4ad9904862b71afa90aa143e94
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miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint

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