Out-of-hospital cardiac arrest and ambient air pollution: A dose-effect relationship and an association with OHCA incidence.

<h4>Background</h4>Pollution has been suggested as a precipitating factor for cardiovascular diseases. However, data about the link between air pollution and the risk of out-of-hospital cardiac arrest (OHCA) are limited and controversial.<h4>Methods</h4>By collecting data bot...

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Autores principales:	Francesca Romana Gentile, Roberto Primi, Enrico Baldi, Sara Compagnoni, Claudio Mare, Enrico Contri, Francesca Reali, Daniele Bussi, Fabio Facchin, Alessia Currao, Sara Bendotti, Simone Savastano, Lombardia CARe researchers
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/833ce75d376447c2a1999077da3d6869
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spelling	oai:doaj.org-article:833ce75d376447c2a1999077da3d68692021-12-02T20:19:34ZOut-of-hospital cardiac arrest and ambient air pollution: A dose-effect relationship and an association with OHCA incidence.1932-620310.1371/journal.pone.0256526https://doaj.org/article/833ce75d376447c2a1999077da3d68692021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256526https://doaj.org/toc/1932-6203<h4>Background</h4>Pollution has been suggested as a precipitating factor for cardiovascular diseases. However, data about the link between air pollution and the risk of out-of-hospital cardiac arrest (OHCA) are limited and controversial.<h4>Methods</h4>By collecting data both in the OHCA registry and in the database of the regional agency for environmental protection (ARPA) of the Lombardy region, all medical OHCAs and the mean daily concentration of pollutants including fine particulate matter (PM10, PM2.5), benzene (C6H6), carbon monoxide (CO), nitrogen dioxide (NO2), sulphur dioxide (SO2), and ozone (O3) were considered from January 1st to December 31st, 2019 in the southern part of the Lombardy region (provinces of Pavia, Lodi, Cremona and Mantua; 7863 km2; about 1550000 inhabitants). Days were divided into high or low incidence of OHCA according to the median value. A Probit dose-response analysis and both uni- and multivariable logistic regression models were provided for each pollutant.<h4>Results</h4>The concentrations of all the pollutants were significantly higher in days with high incidence of OHCA except for O3, which showed a significant countertrend. After correcting for temperature, a significant dose-response relationship was demonstrated for all the pollutants examined. All the pollutants were also strongly associated with high incidence of OHCA in multivariable analysis with correction for temperature, humidity, and day-to-day concentration changes.<h4>Conclusions</h4>Our results clarify the link between pollutants and the acute risk of cardiac arrest suggesting the need of both improving the air quality and integrating pollution data in future models for the organization of emergency medical services.Francesca Romana GentileRoberto PrimiEnrico BaldiSara CompagnoniClaudio MareEnrico ContriFrancesca RealiDaniele BussiFabio FacchinAlessia CurraoSara BendottiSimone SavastanoLombardia CARe researchersPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256526 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Francesca Romana Gentile Roberto Primi Enrico Baldi Sara Compagnoni Claudio Mare Enrico Contri Francesca Reali Daniele Bussi Fabio Facchin Alessia Currao Sara Bendotti Simone Savastano Lombardia CARe researchers Out-of-hospital cardiac arrest and ambient air pollution: A dose-effect relationship and an association with OHCA incidence.
description	<h4>Background</h4>Pollution has been suggested as a precipitating factor for cardiovascular diseases. However, data about the link between air pollution and the risk of out-of-hospital cardiac arrest (OHCA) are limited and controversial.<h4>Methods</h4>By collecting data both in the OHCA registry and in the database of the regional agency for environmental protection (ARPA) of the Lombardy region, all medical OHCAs and the mean daily concentration of pollutants including fine particulate matter (PM10, PM2.5), benzene (C6H6), carbon monoxide (CO), nitrogen dioxide (NO2), sulphur dioxide (SO2), and ozone (O3) were considered from January 1st to December 31st, 2019 in the southern part of the Lombardy region (provinces of Pavia, Lodi, Cremona and Mantua; 7863 km2; about 1550000 inhabitants). Days were divided into high or low incidence of OHCA according to the median value. A Probit dose-response analysis and both uni- and multivariable logistic regression models were provided for each pollutant.<h4>Results</h4>The concentrations of all the pollutants were significantly higher in days with high incidence of OHCA except for O3, which showed a significant countertrend. After correcting for temperature, a significant dose-response relationship was demonstrated for all the pollutants examined. All the pollutants were also strongly associated with high incidence of OHCA in multivariable analysis with correction for temperature, humidity, and day-to-day concentration changes.<h4>Conclusions</h4>Our results clarify the link between pollutants and the acute risk of cardiac arrest suggesting the need of both improving the air quality and integrating pollution data in future models for the organization of emergency medical services.
format	article
author	Francesca Romana Gentile Roberto Primi Enrico Baldi Sara Compagnoni Claudio Mare Enrico Contri Francesca Reali Daniele Bussi Fabio Facchin Alessia Currao Sara Bendotti Simone Savastano Lombardia CARe researchers
author_facet	Francesca Romana Gentile Roberto Primi Enrico Baldi Sara Compagnoni Claudio Mare Enrico Contri Francesca Reali Daniele Bussi Fabio Facchin Alessia Currao Sara Bendotti Simone Savastano Lombardia CARe researchers
author_sort	Francesca Romana Gentile
title	Out-of-hospital cardiac arrest and ambient air pollution: A dose-effect relationship and an association with OHCA incidence.
title_short	Out-of-hospital cardiac arrest and ambient air pollution: A dose-effect relationship and an association with OHCA incidence.
title_full	Out-of-hospital cardiac arrest and ambient air pollution: A dose-effect relationship and an association with OHCA incidence.
title_fullStr	Out-of-hospital cardiac arrest and ambient air pollution: A dose-effect relationship and an association with OHCA incidence.
title_full_unstemmed	Out-of-hospital cardiac arrest and ambient air pollution: A dose-effect relationship and an association with OHCA incidence.
title_sort	out-of-hospital cardiac arrest and ambient air pollution: a dose-effect relationship and an association with ohca incidence.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/833ce75d376447c2a1999077da3d6869
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Out-of-hospital cardiac arrest and ambient air pollution: A dose-effect relationship and an association with OHCA incidence.

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