Sesquiterpenes From Oplopanax elatus Stems and Their Anti-Photoaging Effects by Down-Regulating Matrix Metalloproteinase-1 Expression via Anti-Inflammation

In the process of continuing to investigate ultraviolet b (UVB) irradiation protective constituents from Oplopanax elatus stems, nine new sesquiterpenes, named as eurylosesquiterpenosides A–D (1–4), eurylosesquiterpenols E–I (5–9), and ten known ones (10–19) were gained. Their structures were establ...

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Autores principales:	Jiejing Yan, Mimi Hao, Yu Han, Jingya Ruan, Dandan Zheng, Fan Sun, Huina Cao, Jia Hao, Yi Zhang, Tao Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Oplopanax elatus stems sesquiterpenes HaCaT cells anti-photoaging matrix metalloproteinase-1 mitogen-activated protein kinase Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/833e4aea28cb4a7aa6178466abb0936b
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spelling	oai:doaj.org-article:833e4aea28cb4a7aa6178466abb0936b2021-11-04T07:33:36ZSesquiterpenes From Oplopanax elatus Stems and Their Anti-Photoaging Effects by Down-Regulating Matrix Metalloproteinase-1 Expression via Anti-Inflammation2296-264610.3389/fchem.2021.766041https://doaj.org/article/833e4aea28cb4a7aa6178466abb0936b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fchem.2021.766041/fullhttps://doaj.org/toc/2296-2646In the process of continuing to investigate ultraviolet b (UVB) irradiation protective constituents from Oplopanax elatus stems, nine new sesquiterpenes, named as eurylosesquiterpenosides A–D (1–4), eurylosesquiterpenols E–I (5–9), and ten known ones (10–19) were gained. Their structures were established by analysis of their NMR spectroscopic data, and electronic circular dichroism calculations were applied to define their absolute configurations. In addition, UVB induced HaCaT cells were used to study their anti-photoaging activities and mechanism. The results consolidated that compounds 7, 11, and 14 could improve the survival rate of HaCaT cells in concentration dependent manner at 10, 25, and 50 μM. Furthermore, western blot assay suggested that all of them could inhibit the expression of matrix metalloproteinase-1 (MMP-1), and increase the level of type I collagen markedly. Compounds 11 and 14 could reduce the phosphorylation of extracellular signal-regulated kinase and p38, respectively. Besides, compounds 7, 11, and 14 could significantly down-regulate the expression of inflammation related protein, such as tumor necrosis factor-α and cyclooxygenase-2, which indicated that they played anti-photoaging activities by reducing MMP-1 expression via down-regulating the production of inflammatory mediators and cytokines in UVB-induced HaCaT cells.Jiejing YanMimi HaoYu HanJingya RuanDandan ZhengFan SunHuina CaoJia HaoYi ZhangYi ZhangTao WangTao WangFrontiers Media S.A.articleOplopanax elatus stemssesquiterpenesHaCaT cellsanti-photoagingmatrix metalloproteinase-1mitogen-activated protein kinaseChemistryQD1-999ENFrontiers in Chemistry, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Oplopanax elatus stems sesquiterpenes HaCaT cells anti-photoaging matrix metalloproteinase-1 mitogen-activated protein kinase Chemistry QD1-999
spellingShingle	Oplopanax elatus stems sesquiterpenes HaCaT cells anti-photoaging matrix metalloproteinase-1 mitogen-activated protein kinase Chemistry QD1-999 Jiejing Yan Mimi Hao Yu Han Jingya Ruan Dandan Zheng Fan Sun Huina Cao Jia Hao Yi Zhang Yi Zhang Tao Wang Tao Wang Sesquiterpenes From Oplopanax elatus Stems and Their Anti-Photoaging Effects by Down-Regulating Matrix Metalloproteinase-1 Expression via Anti-Inflammation
description	In the process of continuing to investigate ultraviolet b (UVB) irradiation protective constituents from Oplopanax elatus stems, nine new sesquiterpenes, named as eurylosesquiterpenosides A–D (1–4), eurylosesquiterpenols E–I (5–9), and ten known ones (10–19) were gained. Their structures were established by analysis of their NMR spectroscopic data, and electronic circular dichroism calculations were applied to define their absolute configurations. In addition, UVB induced HaCaT cells were used to study their anti-photoaging activities and mechanism. The results consolidated that compounds 7, 11, and 14 could improve the survival rate of HaCaT cells in concentration dependent manner at 10, 25, and 50 μM. Furthermore, western blot assay suggested that all of them could inhibit the expression of matrix metalloproteinase-1 (MMP-1), and increase the level of type I collagen markedly. Compounds 11 and 14 could reduce the phosphorylation of extracellular signal-regulated kinase and p38, respectively. Besides, compounds 7, 11, and 14 could significantly down-regulate the expression of inflammation related protein, such as tumor necrosis factor-α and cyclooxygenase-2, which indicated that they played anti-photoaging activities by reducing MMP-1 expression via down-regulating the production of inflammatory mediators and cytokines in UVB-induced HaCaT cells.
format	article
author	Jiejing Yan Mimi Hao Yu Han Jingya Ruan Dandan Zheng Fan Sun Huina Cao Jia Hao Yi Zhang Yi Zhang Tao Wang Tao Wang
author_facet	Jiejing Yan Mimi Hao Yu Han Jingya Ruan Dandan Zheng Fan Sun Huina Cao Jia Hao Yi Zhang Yi Zhang Tao Wang Tao Wang
author_sort	Jiejing Yan
title	Sesquiterpenes From Oplopanax elatus Stems and Their Anti-Photoaging Effects by Down-Regulating Matrix Metalloproteinase-1 Expression via Anti-Inflammation
title_short	Sesquiterpenes From Oplopanax elatus Stems and Their Anti-Photoaging Effects by Down-Regulating Matrix Metalloproteinase-1 Expression via Anti-Inflammation
title_full	Sesquiterpenes From Oplopanax elatus Stems and Their Anti-Photoaging Effects by Down-Regulating Matrix Metalloproteinase-1 Expression via Anti-Inflammation
title_fullStr	Sesquiterpenes From Oplopanax elatus Stems and Their Anti-Photoaging Effects by Down-Regulating Matrix Metalloproteinase-1 Expression via Anti-Inflammation
title_full_unstemmed	Sesquiterpenes From Oplopanax elatus Stems and Their Anti-Photoaging Effects by Down-Regulating Matrix Metalloproteinase-1 Expression via Anti-Inflammation
title_sort	sesquiterpenes from oplopanax elatus stems and their anti-photoaging effects by down-regulating matrix metalloproteinase-1 expression via anti-inflammation
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/833e4aea28cb4a7aa6178466abb0936b
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Sesquiterpenes From Oplopanax elatus Stems and Their Anti-Photoaging Effects by Down-Regulating Matrix Metalloproteinase-1 Expression via Anti-Inflammation

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