Mutations of different molecular origins exhibit contrasting patterns of regional substitution rate variation.

Transitions at CpG dinucleotides, referred to as "CpG substitutions", are a major mutational input into vertebrate genomes and a leading cause of human genetic disease. The prevalence of CpG substitutions is due to their mutational origin, which is dependent on DNA methylation. In comparis...

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Autores principales: Navin Elango, Seong-Ho Kim, Eric Vigoda, Soojin V Yi
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2008
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Acceso en línea:https://doaj.org/article/833e7632d73b4400a36329e85caafe11
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