Mutations of different molecular origins exhibit contrasting patterns of regional substitution rate variation.
Transitions at CpG dinucleotides, referred to as "CpG substitutions", are a major mutational input into vertebrate genomes and a leading cause of human genetic disease. The prevalence of CpG substitutions is due to their mutational origin, which is dependent on DNA methylation. In comparis...
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| Auteurs principaux: | , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Public Library of Science (PLoS)
2008
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| Accès en ligne: | https://doaj.org/article/833e7632d73b4400a36329e85caafe11 |
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