Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction

Sammy Alhassen, Siwei Chen, et al. use mouse models to examine the effects of prenatal and postnatal stress on metabolomic and transcriptomic pathways in the brain. Their results suggest that altered mitochondrial metabolism may underlie trauma-induced behavioral deficits, and that correcting metabo...

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Autores principales:	Sammy Alhassen, Siwei Chen, Lamees Alhassen, Alvin Phan, Mohammad Khoudari, Angele De Silva, Huda Barhoosh, Zitong Wang, Chelsea Parrocha, Emily Shapiro, Charity Henrich, Zicheng Wang, Leon Mutesa, Pierre Baldi, Geoffrey W. Abbott, Amal Alachkar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8349a6b2dd754f9e98b7e196962d95a5
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spelling	oai:doaj.org-article:8349a6b2dd754f9e98b7e196962d95a52021-12-02T17:45:20ZIntergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction10.1038/s42003-021-02255-22399-3642https://doaj.org/article/8349a6b2dd754f9e98b7e196962d95a52021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02255-2https://doaj.org/toc/2399-3642Sammy Alhassen, Siwei Chen, et al. use mouse models to examine the effects of prenatal and postnatal stress on metabolomic and transcriptomic pathways in the brain. Their results suggest that altered mitochondrial metabolism may underlie trauma-induced behavioral deficits, and that correcting metabolism with ALCAR supplementation may protect against intergenerational transmission of traumatic stress.Sammy AlhassenSiwei ChenLamees AlhassenAlvin PhanMohammad KhoudariAngele De SilvaHuda BarhooshZitong WangChelsea ParrochaEmily ShapiroCharity HenrichZicheng WangLeon MutesaPierre BaldiGeoffrey W. AbbottAmal AlachkarNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Sammy Alhassen Siwei Chen Lamees Alhassen Alvin Phan Mohammad Khoudari Angele De Silva Huda Barhoosh Zitong Wang Chelsea Parrocha Emily Shapiro Charity Henrich Zicheng Wang Leon Mutesa Pierre Baldi Geoffrey W. Abbott Amal Alachkar Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction
description	Sammy Alhassen, Siwei Chen, et al. use mouse models to examine the effects of prenatal and postnatal stress on metabolomic and transcriptomic pathways in the brain. Their results suggest that altered mitochondrial metabolism may underlie trauma-induced behavioral deficits, and that correcting metabolism with ALCAR supplementation may protect against intergenerational transmission of traumatic stress.
format	article
author	Sammy Alhassen Siwei Chen Lamees Alhassen Alvin Phan Mohammad Khoudari Angele De Silva Huda Barhoosh Zitong Wang Chelsea Parrocha Emily Shapiro Charity Henrich Zicheng Wang Leon Mutesa Pierre Baldi Geoffrey W. Abbott Amal Alachkar
author_facet	Sammy Alhassen Siwei Chen Lamees Alhassen Alvin Phan Mohammad Khoudari Angele De Silva Huda Barhoosh Zitong Wang Chelsea Parrocha Emily Shapiro Charity Henrich Zicheng Wang Leon Mutesa Pierre Baldi Geoffrey W. Abbott Amal Alachkar
author_sort	Sammy Alhassen
title	Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction
title_short	Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction
title_full	Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction
title_fullStr	Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction
title_full_unstemmed	Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction
title_sort	intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8349a6b2dd754f9e98b7e196962d95a5
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Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction

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