Design of the novel ThermoBrachy applicators enabling simultaneous interstitial hyperthermia and high dose rate brachytherapy

Objective In High Dose Rate Brachytherapy for prostate cancer there is a need for a new way of increasing cancer cell kill in combination with a stable dose to the organs at risk. In this study, we propose a novel ThermoBrachy applicator that offers the unique ability to apply interstitial hyperther...

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Autores principales:	Ioannis Androulakis, Rob M. C. Mestrom, Miranda E. M. C. Christianen, Inger-Karine K. Kolkman-Deurloo, Gerard C. van Rhoon
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	interstitial hyperthermia high dose rate brachytherapy prostate cancer dynamic temperature steering hyperthermia applicator Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/834d7e11b6184a3facab3b26b46bd212
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spelling	oai:doaj.org-article:834d7e11b6184a3facab3b26b46bd2122021-11-26T11:19:46ZDesign of the novel ThermoBrachy applicators enabling simultaneous interstitial hyperthermia and high dose rate brachytherapy0265-67361464-515710.1080/02656736.2021.2005160https://doaj.org/article/834d7e11b6184a3facab3b26b46bd2122021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/02656736.2021.2005160https://doaj.org/toc/0265-6736https://doaj.org/toc/1464-5157Objective In High Dose Rate Brachytherapy for prostate cancer there is a need for a new way of increasing cancer cell kill in combination with a stable dose to the organs at risk. In this study, we propose a novel ThermoBrachy applicator that offers the unique ability to apply interstitial hyperthermia while simultaneously serving as an afterloading catheter for high dose rate brachytherapy for prostate cancer. This approach achieves a higher thermal enhancement ratio than in sequential application of radiation and hyperthermia and has the potential to decrease the overall treatment time. Methods The new applicator uses the principle of capacitively coupled electrodes. We performed a proof of concept experiment to demostrate the feasibility of the proposed applicator. Moreover, we used electromagnetic and thermal simulations to evaluate the power needs and temperature homogeneity in different tissues. Furthermore we investigated whether dynamic phase and amplitude adaptation can be used to improve longitudinal temperature control. Results Simulations demonstrate that the electrodes achieve good temperature homogeneity in a homogenous phantom when following current applicator spacing guidelines. Furthermore, we demonstrate that by dynamic phase and amplitude adaptation provides a great advancement for further adaptability of the heating pattern. Conclusions This newly designed ThermoBrachy applicator has the potential to revise the interest in interstitial thermobrachytherapy, since the simultaneous application of radiation and hyperthermia enables maximum thermal enhancement and at maximum efficiency for patient and organization.Ioannis AndroulakisRob M. C. MestromMiranda E. M. C. ChristianenInger-Karine K. Kolkman-DeurlooGerard C. van RhoonTaylor & Francis Grouparticleinterstitial hyperthermiahigh dose rate brachytherapyprostate cancerdynamic temperature steeringhyperthermia applicatorMedical technologyR855-855.5ENInternational Journal of Hyperthermia, Vol 38, Iss 1, Pp 1660-1671 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	interstitial hyperthermia high dose rate brachytherapy prostate cancer dynamic temperature steering hyperthermia applicator Medical technology R855-855.5
spellingShingle	interstitial hyperthermia high dose rate brachytherapy prostate cancer dynamic temperature steering hyperthermia applicator Medical technology R855-855.5 Ioannis Androulakis Rob M. C. Mestrom Miranda E. M. C. Christianen Inger-Karine K. Kolkman-Deurloo Gerard C. van Rhoon Design of the novel ThermoBrachy applicators enabling simultaneous interstitial hyperthermia and high dose rate brachytherapy
description	Objective In High Dose Rate Brachytherapy for prostate cancer there is a need for a new way of increasing cancer cell kill in combination with a stable dose to the organs at risk. In this study, we propose a novel ThermoBrachy applicator that offers the unique ability to apply interstitial hyperthermia while simultaneously serving as an afterloading catheter for high dose rate brachytherapy for prostate cancer. This approach achieves a higher thermal enhancement ratio than in sequential application of radiation and hyperthermia and has the potential to decrease the overall treatment time. Methods The new applicator uses the principle of capacitively coupled electrodes. We performed a proof of concept experiment to demostrate the feasibility of the proposed applicator. Moreover, we used electromagnetic and thermal simulations to evaluate the power needs and temperature homogeneity in different tissues. Furthermore we investigated whether dynamic phase and amplitude adaptation can be used to improve longitudinal temperature control. Results Simulations demonstrate that the electrodes achieve good temperature homogeneity in a homogenous phantom when following current applicator spacing guidelines. Furthermore, we demonstrate that by dynamic phase and amplitude adaptation provides a great advancement for further adaptability of the heating pattern. Conclusions This newly designed ThermoBrachy applicator has the potential to revise the interest in interstitial thermobrachytherapy, since the simultaneous application of radiation and hyperthermia enables maximum thermal enhancement and at maximum efficiency for patient and organization.
format	article
author	Ioannis Androulakis Rob M. C. Mestrom Miranda E. M. C. Christianen Inger-Karine K. Kolkman-Deurloo Gerard C. van Rhoon
author_facet	Ioannis Androulakis Rob M. C. Mestrom Miranda E. M. C. Christianen Inger-Karine K. Kolkman-Deurloo Gerard C. van Rhoon
author_sort	Ioannis Androulakis
title	Design of the novel ThermoBrachy applicators enabling simultaneous interstitial hyperthermia and high dose rate brachytherapy
title_short	Design of the novel ThermoBrachy applicators enabling simultaneous interstitial hyperthermia and high dose rate brachytherapy
title_full	Design of the novel ThermoBrachy applicators enabling simultaneous interstitial hyperthermia and high dose rate brachytherapy
title_fullStr	Design of the novel ThermoBrachy applicators enabling simultaneous interstitial hyperthermia and high dose rate brachytherapy
title_full_unstemmed	Design of the novel ThermoBrachy applicators enabling simultaneous interstitial hyperthermia and high dose rate brachytherapy
title_sort	design of the novel thermobrachy applicators enabling simultaneous interstitial hyperthermia and high dose rate brachytherapy
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/834d7e11b6184a3facab3b26b46bd212
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Design of the novel ThermoBrachy applicators enabling simultaneous interstitial hyperthermia and high dose rate brachytherapy

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