Linkers of cell polarity and cell cycle regulation in the fission yeast protein interaction network.

The study of gene and protein interaction networks has improved our understanding of the multiple, systemic levels of regulation found in eukaryotic and prokaryotic organisms. Here we carry out a large-scale analysis of the protein-protein interaction (PPI) network of fission yeast (Schizosaccharomy...

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Autores principales:	Federico Vaggi, James Dodgson, Archana Bajpai, Anatole Chessel, Ferenc Jordán, Masamitsu Sato, Rafael Edgardo Carazo-Salas, Attila Csikász-Nagy
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8352e48d29bb4677b076cfb00b3239c9
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spelling	oai:doaj.org-article:8352e48d29bb4677b076cfb00b3239c92021-11-18T05:52:47ZLinkers of cell polarity and cell cycle regulation in the fission yeast protein interaction network.1553-734X1553-735810.1371/journal.pcbi.1002732https://doaj.org/article/8352e48d29bb4677b076cfb00b3239c92012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23093924/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358The study of gene and protein interaction networks has improved our understanding of the multiple, systemic levels of regulation found in eukaryotic and prokaryotic organisms. Here we carry out a large-scale analysis of the protein-protein interaction (PPI) network of fission yeast (Schizosaccharomyces pombe) and establish a method to identify 'linker' proteins that bridge diverse cellular processes - integrating Gene Ontology and PPI data with network theory measures. We test the method on a highly characterized subset of the genome consisting of proteins controlling the cell cycle, cell polarity and cytokinesis and identify proteins likely to play a key role in controlling the temporal changes in the localization of the polarity machinery. Experimental inspection of one such factor, the polarity-regulating RNB protein Sts5, confirms the prediction that it has a cell cycle dependent regulation. Detailed bibliographic inspection of other predicted 'linkers' also confirms the predictive power of the method. As the method is robust to network perturbations and can successfully predict linker proteins, it provides a powerful tool to study the interplay between different cellular processes.Federico VaggiJames DodgsonArchana BajpaiAnatole ChesselFerenc JordánMasamitsu SatoRafael Edgardo Carazo-SalasAttila Csikász-NagyPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 8, Iss 10, p e1002732 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Federico Vaggi James Dodgson Archana Bajpai Anatole Chessel Ferenc Jordán Masamitsu Sato Rafael Edgardo Carazo-Salas Attila Csikász-Nagy Linkers of cell polarity and cell cycle regulation in the fission yeast protein interaction network.
description	The study of gene and protein interaction networks has improved our understanding of the multiple, systemic levels of regulation found in eukaryotic and prokaryotic organisms. Here we carry out a large-scale analysis of the protein-protein interaction (PPI) network of fission yeast (Schizosaccharomyces pombe) and establish a method to identify 'linker' proteins that bridge diverse cellular processes - integrating Gene Ontology and PPI data with network theory measures. We test the method on a highly characterized subset of the genome consisting of proteins controlling the cell cycle, cell polarity and cytokinesis and identify proteins likely to play a key role in controlling the temporal changes in the localization of the polarity machinery. Experimental inspection of one such factor, the polarity-regulating RNB protein Sts5, confirms the prediction that it has a cell cycle dependent regulation. Detailed bibliographic inspection of other predicted 'linkers' also confirms the predictive power of the method. As the method is robust to network perturbations and can successfully predict linker proteins, it provides a powerful tool to study the interplay between different cellular processes.
format	article
author	Federico Vaggi James Dodgson Archana Bajpai Anatole Chessel Ferenc Jordán Masamitsu Sato Rafael Edgardo Carazo-Salas Attila Csikász-Nagy
author_facet	Federico Vaggi James Dodgson Archana Bajpai Anatole Chessel Ferenc Jordán Masamitsu Sato Rafael Edgardo Carazo-Salas Attila Csikász-Nagy
author_sort	Federico Vaggi
title	Linkers of cell polarity and cell cycle regulation in the fission yeast protein interaction network.
title_short	Linkers of cell polarity and cell cycle regulation in the fission yeast protein interaction network.
title_full	Linkers of cell polarity and cell cycle regulation in the fission yeast protein interaction network.
title_fullStr	Linkers of cell polarity and cell cycle regulation in the fission yeast protein interaction network.
title_full_unstemmed	Linkers of cell polarity and cell cycle regulation in the fission yeast protein interaction network.
title_sort	linkers of cell polarity and cell cycle regulation in the fission yeast protein interaction network.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/8352e48d29bb4677b076cfb00b3239c9
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Linkers of cell polarity and cell cycle regulation in the fission yeast protein interaction network.

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